1. Apoptosis
    Cell Cycle/DNA Damage
  2. Caspase
    Apoptosis
    Topoisomerase
  3. Phenoxodiol

Phenoxodiol (Synonyms: Idronoxil; Dehydroequol; Haginin E)

目录号: HY-13721 纯度: >98.0%
产品使用指南

Phenoxodiol是一种合成genestein的类似物,激活线粒体caspase系统,抑制XIAP(一个凋亡抑制剂),使癌细胞对fas介导的凋亡敏感。Phenoxodiol还通过稳定可分裂复合物抑制DNA拓扑异构酶II,从而阻止DNA复制。Phenoxodiol 在细胞周期的G1/S期诱导细胞周期阻滞,通过独立于p53的方式上调p21WAF1

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Phenoxodiol Chemical Structure

Phenoxodiol Chemical Structure

CAS No. : 81267-65-4

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Description

Phenoxodiol, a synthetic analog of Genestein, activates the mitochondrial caspase system, inhibits XIAP (an apoptosis inhibitor), and sensitizes the cancer cells to Fas-mediated apoptosis. This agent also inhibits DNA topoisomerase II by stabilizing the cleavable complex. Phenoxodiol induces cell cycle arrest in the G1/S phase of the cell cycle and upregulates p21WAF1 via a p53 independent manner[1][2].

IC50 & Target

Caspase, DNA topoisomerase II[1][2].

Clinical Trial
Molecular Weight

240.25

Formula

C₁₅H₁₂O₃

CAS No.

81267-65-4

SMILES

OC1=CC=C2C=C(C3=CC=C(O)C=C3)COC2=C1

Shipping

Room temperature in continental US; may vary elsewhere

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
References

Purity: >98.0%

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
Phenoxodiol
目录号:
HY-13721
需求量:

Phenoxodiol

Cat. No.: HY-13721