1. Neuronal Signaling
  2. AChE
  3. Physostigmine salicylate

Physostigmine salicylate (Synonyms: 水杨酸毒扁豆碱; Eserine salicylate)

目录号: HY-B1266
产品使用指南

Physostigmine salicylate (Eserine salicylate) 是一种可逆的乙酰胆碱酯酶 (AChE) 抑制剂。Physostigmine salicylate 可以透过血脑屏障并刺激中枢胆碱能神经传递。Physostigmine salicylate能逆转阿尔茨海默病转基因小鼠的记忆缺陷。Physostigmine salicylate 也是抗胆碱能中毒的解毒剂。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

Physostigmine salicylate Chemical Structure

Physostigmine salicylate Chemical Structure

CAS No. : 57-64-7

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Other Forms of Physostigmine salicylate:

Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

Description

Physostigmine salicylate (Eserine salicylate) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine hemisulfate salicylatecan crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine salicylate can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine salicylate is also an antidote for anticholinergic poisoning[1][2][3][4].

In Vivo

Physostigmine salicylate (Eserine salicylate; 0.03-0.3 mg/kg; s.c.; daily for 6 weeks) improves deficits in contextual and cued memory in Tg(+) mice[2].
Physostigmine salicylate (IV; 0.1, 0.2 mg/kg) delays time to emergence from isoflurane anesthesia at doses ≥0.2 mg/kg in male Sprague-Dawley rats[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Heterozygous transgenic mice (Tg(+) mice)[2]
Dosage: 0.03, 0.1, and 0.3 mg/kg
Administration: SC; daily for 6 weeks
Result: Tended to normalize the contextual memory deficit in Tg(+) animals so that they became more similar to Tg(-) animals.
Molecular Weight

413.47

Formula

C₂₂H₂₇N₃O₅

CAS No.

57-64-7

中文名称

水杨酸毒扁豆碱

SMILES

O=C(O)C1=CC=CC=C1O.O=C(OC2=CC3=C(N(C)[C@]4([H])[C@@]3(C)CCN4C)C=C2)NC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

PhysostigmineEserineAChEAcetylcholinesteraseblood-brainbarrierAlzheimer'santidoteInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
Physostigmine salicylate
目录号:
HY-B1266
需求量: