1. GPCR/G Protein
  2. Guanylate Cyclase
  3. Plecanatide

Plecanatide  (Synonyms: 普卡那肽)

目录号: HY-108741 纯度: 98.14%
COA 产品使用指南

Plecanatide 是尿鸟苷蛋白的类似物,是一种具有口服活性的鸟苷酸环化酶 C 受体 (guanylate cyclase-C (GC-C) receptor) 激动剂,在 T84 细胞实验中激活 GC-C 受体以刺激 cGMP 合成的 EC50 值为 190 nM。Plecanatide 在小鼠结肠炎模型中具有抗炎活性。

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Plecanatide Chemical Structure

Plecanatide Chemical Structure

CAS No. : 467426-54-6

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1 mg ¥900
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5 mg ¥2300
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10 mg ¥3800
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25 mg ¥6500
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Other Forms of Plecanatide:

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Plecanatide, an analogue of Uroguanylin, is an orally active guanylate cyclase-C (GC-C) receptor agonist. Plecanatide activates GC-C receptors to stimulate cGMP synthesis with an EC50 of 190 nM in T84 cells assay. Plecanatide shows anti-inflammatory activity in models of murine colitis[1][2][3].

IC50 & Target

EC50: 190 nM (guanylate cyclase-C)[1]

体外研究
(In Vitro)

Plecanatide (1 nM-10 μM) activates GC-C receptor to stimulate cyclic guanosine monophosphate (cGMP) synthesis in a dose-dependent manner with EC50 of 190 nM in T84 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Plecanatide (0.5 and 2.5 mg/kg, p.o.) ameliorates spontaneous and chemically induced colitis after treatment for 7 days in BALB/c mice, and 14 days in TCRα-/- mice[1].
Plecanatide (0.005-5 mg/kg, once daily for 7 days) also shows anti-inflammatory activity in dextran sulfate sodium (DSS) and trinitrobenzene sulfonic (TNBS)-induced colitis in BDF-1 mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c mice (2-4 month old) are induced colitis by TNBS[1]
Dosage: 0, 0.5 and 2.5 mg/kg
Administration: P.o. for 7 days
Result: Effectively reduced colitis severity scores as compared to vehicle treatment.
Clinical Trial
分子量

1681.89

Formula

C65H104N18O26S4

CAS 号
性状

固体

颜色

White to off-white

Sequence

Asn-Asp-Glu-Cys-Glu-Leu-Cys-Val-Asn-Val-Ala-Cys-Thr-Gly-Cys-Leu (Disulfide bridge: Cys4-Cys12; Cys7-Cys15)

Sequence Shortening

NDECELCVNVACTGCL (Disulfide bridge: Cys4-Cys12; Cys7-Cys15)

中文名称

普卡那肽

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 100 mg/mL (59.46 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.5946 mL 2.9728 mL 5.9457 mL
5 mM 0.1189 mL 0.5946 mL 1.1891 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Plecanatide 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.5946 mL 2.9728 mL 5.9457 mL 14.8642 mL
5 mM 0.1189 mL 0.5946 mL 1.1891 mL 2.9728 mL
10 mM 0.0595 mL 0.2973 mL 0.5946 mL 1.4864 mL
15 mM 0.0396 mL 0.1982 mL 0.3964 mL 0.9909 mL
20 mM 0.0297 mL 0.1486 mL 0.2973 mL 0.7432 mL
25 mM 0.0238 mL 0.1189 mL 0.2378 mL 0.5946 mL
30 mM 0.0198 mL 0.0991 mL 0.1982 mL 0.4955 mL
40 mM 0.0149 mL 0.0743 mL 0.1486 mL 0.3716 mL
50 mM 0.0119 mL 0.0595 mL 0.1189 mL 0.2973 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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目录号:
HY-108741
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