1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugate
  3. Pomalidomide-amido-C1-Br

Pomalidomide-amido-C1-Br 

目录号: HY-130617
产品使用指南

Pomalidomide-amido-C1-Br 是一种合成的 E3 连接酶配体-linker 偶联物,包含基于 Pomalidomide 的 cereblon 配体和 1 个 linker。Pomalidomide-amido-C1-Br 可通过 PROTAC 技术合成 B-Raf 降解剂 PROTAC B-Raf degrader 1 (HY-111758)。PROTAC B-Raf degrader 1 具有抗肿瘤活性。

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Pomalidomide-amido-C1-Br Chemical Structure

Pomalidomide-amido-C1-Br Chemical Structure

CAS No. : 2351106-38-0

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Description

Pomalidomide-amido-C1-Br is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker. Pomalidomide-amido-C1-Br can be used to design a B-Raf PROTAC degrader PROTAC B-Raf degrader 1 (HY-111758). PROTAC B-Raf degrader 1 has anti-cancer activity[1].

IC50 & Target[1]

Cereblon

 

In Vitro

Pomalidomide-amido-C1-Br (Compound 6) can be used to design a B-Raf PROTAC degrader PROTAC B-Raf degrader 1 (Compound 2). PROTAC B-Raf degrader 1 can effectively kill cancer cells via inducing cells apoptosis. As a B-Raf degrader, PROTAC B-Raf degrader 1 can accelerate the degradation of B-Raf by recruiting ubiquitin-proteasome system, and further affects the expression of Mcl-1, a downstream protein of B-Raf[1].

Molecular Weight

394.18

Formula

C₁₅H₁₂BrN₃O₅

CAS No.

2351106-38-0

SMILES

O=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CBr

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Pomalidomide-amido-C1-BrE3 Ligase Ligand-Linker ConjugatePomalidomidecereblonPROTACdegraderB-RafInhibitorinhibitorinhibit

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产品名称:
Pomalidomide-amido-C1-Br
目录号:
HY-130617
需求量: