1. PROTAC
  2. E3 Ligase Ligand-Linker Conjugate
  3. Pomalidomide-amido-PEG3-C2-NH2

Pomalidomide-amido-PEG3-C2-NH2 (Synonyms: Cereblon Ligand-Linker Conjugates 22; E3 ligase Ligand-Linker Conjugates 55)

目录号: HY-130521
产品使用指南

Pomalidomide-amido-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 22) 是一种合成的 E3 连接酶配体-linker 偶联物,包含基于 Pomalidomide 的 cereblon 配体和 3 个单元 PEG 的 linker。

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Pomalidomide-amido-PEG3-C2-NH2 Chemical Structure

Pomalidomide-amido-PEG3-C2-NH2 Chemical Structure

CAS No. : 2328070-52-4

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Description

Pomalidomide-amido-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 22) is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 3-unit PEG linker used in PROTAC technology[1].

IC50 & Target[1]

Cereblon

 

In Vitro

Pomalidomide-amido-PEG3-C2-NH2 (Compound 5b) can be used to synthesize BI-3663. BI-3663 (cereblon-based) degrades focal adhesion tyrosine kinase (PTK2) with a median DC50 of 30 nM to >80% across a panel of 11 human hepatocellular carcinoma (HCC) cell lines[1].

Molecular Weight

476.48

Formula

C₂₂H₂₈N₄O₈

CAS No.

2328070-52-4

SMILES

O=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)CCOCCOCCOCCN

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Pomalidomide-amido-PEG3-C2-NH2Cereblon Ligand-Linker Conjugates 22E3 ligase Ligand-Linker Conjugates 55E3 Ligase Ligand-Linker ConjugatePROTACBI-3663PTK2aminesE3ligasecereblonInhibitorinhibitorinhibit

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产品名称:
Pomalidomide-amido-PEG3-C2-NH2
目录号:
HY-130521
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