2. GPCR/G Protein Stem Cell/Wnt JAK/STAT Signaling
  3. LPL Receptor STAT
  4. pro-FTY

pro-FTY 是一种 FTY720 (HY-12005) 抗癌前药，是一种鞘氨醇-1-磷酸 (S1P) (HY-108496) 抑制剂。pro-FTY 通过与 acrolein 发生反应的药物递送系统 (DDS) 特异性抑制癌细胞中 S1P 的信号传导。pro-FTY 显著抑制乳腺癌细胞的存活，包括对 Paclitaxel (HY-B0015) 或 Doxorubicin (HY-15142A) 有耐药性的多耐药细胞及其类器官。pro-FTY 可有效抑制 4T1 细胞或类器官异种移植肿瘤小鼠模型中的肿瘤生长，同时避免淋巴细胞减少。

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pro-FTY

pro-FTY Chemical Structure

CAS No. : 3064707-13-4

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规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

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pro-FTY 相关抗体

Top Publications Citing Use of Products

查看 LPL Receptor 亚型特异性产品:

查看所有亚型
LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5

查看 STAT 亚型特异性产品:

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STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

pro-FTY, a FTY720 (HY-12005) anticancer prodrug, is a sphingosine-1-phosphate (S1P) (HY-108496) inhibitor. pro-FTY specifically inhibits S1P signaling in cancer cells using a drug delivery system (DDS) that reacts with acrolein. pro-FTY significantly inhibits the survival of breast cancer cells, including multidrug-resistant cells and its organoids resistant to Paclitaxel (HY-B0015) or Doxorubicin (HY-15142A). pro-FTY potently suppresses tumor growth in 4T1 cells or organoids xenograft tumors mice model while avoiding lymphocytopenia[1].

IC50 & Target[1]

p-STAT3

 

分子量

566.77

Formula

C33H50N4O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

pro-FTY 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

pro-FTY3064707-13-4LPL ReceptorSTATLysophospholipid ReceptorAnticancerProdrugFTY720AcroleinSphingosine-1-phosphateS1PDrug delivery systemDDSLymphocytopeniaMDA-MB-468MCF-10 cellsOrganoids4T1 cells xenograft tumors mice modelorganoids xenograft tumors mice modelInhibitorinhibitorinhibit

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目录号：
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