2. PROTAC Protein Tyrosine Kinase/RTK
  3. PROTACs FGFR
  4. PROTAC FGFR1 degrader-1

PROTAC FGFR1 degrader-1 (compound S2H) 是靶向 FGFR1 的 PROTAC 降解剂，在 KG1a 细胞中的 IC50=26.81 nM，DC50=39.78 nM。PROTAC FGFR1 degrader-1 由 CRBN 型 E3 连接酶配体 (blue part) Pomalidomide (HY-10984)，靶蛋白配体 (red part) FGFR1 ligand-1 (HY-170871)，PROTAC linker (black part) 9-Bromononanoic acid (HY-W007587) 组成，其中 E3 连接酶配体和 linker 组成偶联物 E3 Ligase Ligand-linker Conjugate 164 (HY-170870)。

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PROTAC FGFR1 degrader-1 Chemical Structure

PROTAC FGFR1 degrader-1 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

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PROTAC FGFR1 degrader-1 相关抗体

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PROTAC FGFR1 degrader-1 (compound S2H) is a PROTAC degrader targeting FGFR1, with IC50=26.81 nM and DC50=39.78 nM in KG1a cells. PROTAC FGFR1 degrader-1 is composed of CRBN-type E3 ligase ligand (blue part) Pomalidomide (HY-10984), target protein ligand (red part) FGFR1 ligand-1 (HY-170871), and PROTAC linker (black part) 9-Bromononanoic acid (HY-W007587), in which the E3 ligase ligand and linker form a conjugate E3 Ligase Ligand-linker Conjugate 164 (HY-170870)[1].

IC50 & Target

FGFR1[1]
分子量

846.97

Formula

C46H54N8O8
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

PROTAC FGFR1 degrader-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PROTAC FGFR1 degrader-1PROTACsFGFRFibroblast growth factor receptorInhibitorinhibitorinhibit

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