1. Antibody-drug Conjugate/ADC Related Anti-infection
  2. ADC Cytotoxin Bacterial
  3. Py-MPB-amino-C3-PBD

Py-MPB-amino-C3-PBD 是一种细胞毒性活性分子,可作为 ADC 的有效载荷。具有抗微生物活性。

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Py-MPB-amino-C3-PBD Chemical Structure

Py-MPB-amino-C3-PBD Chemical Structure

CAS No. : 2412924-07-1

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  • 生物活性

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生物活性

Py-MPB-amino-C3-PBD is a cytotoxic agent comprised non-alkylating group. Py-MPB-amino-C3-PBD acts as the payload for ADCs. Antimicrobial activity[1].

IC50 & Target[1] [1] [1]

Pyrrolobenzodiazepines

 

体外研究
(In Vitro)

Py-MPB-amino-C3-PBD (compound 73) shows cytotoxicity with IC50s of 301, 144.1 and 37.5 nM for U138-MG, A431, and REH cells, respectively. Py-MPB-amino-C3-PBD possesses potent anti-bacterial effects against the gram negative strain E. coli K12, with potency of 2 pg/mL determined[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

744.84

Formula

C41H44N8O6

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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