2. Cell Cycle/DNA Damage
  3. G-quadruplex
  4. Pyridostatin trihydrochloride

Pyridostatin trihydrochloride  (Synonyms: RR82 trihydrochloride)

目录号: HY-15176C
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Pyridostatin (RR82) trihydrochloride 是一种高选择性的 G-quadruplex DNA 稳定剂 (Kd=490 nM)，可靶向细胞中的 DNA 和 RNA G4s。Pyridostatin trihydrochloride 通过诱导复制和转录依赖的 DNA 损伤促进人类癌细胞生长停滞。Pyridostatin trihydrochloride 靶向原癌基因 Src。Pyridostatin trihydrochloride 降低人乳腺癌细胞 SRC 蛋白水平和 SRC 依赖的细胞运动。

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Pyridostatin trihydrochloride

Pyridostatin trihydrochloride Chemical Structure

CAS No. : 2517456-88-9

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规格 价格 是否有货 数量
1 mg ￥520
1 - 2 周
5 mg ￥1120
1 - 2 周
10 mg ￥1696
1 - 2 周
25 mg ￥3040
1 - 2 周
50 mg   询价  
100 mg   询价  

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Other Forms of Pyridostatin trihydrochloride:

Pyridostatin trihydrochloride 相关抗体

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MCE 顾客使用本产品发表的 29 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pyridostatin (RR82) trihydrochloride is a G-quadruplex DNA stabilizing agent (Kd=490 nM) and can target DNA and RNA G4s in cells. Pyridostatin trihydrochloride promotes growth arrest in human cancer cells by inducing replication- and transcription-dependent DNA damage. Pyridostatin trihydrochloride targets the proto-oncogene Src. Pyridostatin trihydrochloride reduced SRC protein levels and SRC-dependent cellular motility in human breast cancer cells[1][2].

分子量

706.02

Formula

C31H35Cl3N8O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Pyridostatin trihydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pyridostatin trihydrochloride2517456-88-9RR82 trihydrochlorideG-quadruplexstructureDNAdamageneurodegenerationDSBcyclearrestSRCInhibitorinhibitorinhibit

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