5HT1B 蛋白, Human (Cell-Free, His)

The 5HT1B protein is a G-protein-coupled receptor for serotonin, ergot alkaloids, and psychoactive substances that undergoes conformational changes upon ligand binding, modulating downstream effectors and inhibiting adenylyl cyclase activity. Inhibin inhibits G protein signaling and activates alternative pathways. 5HT1B Protein, Human (Cell-Free, His) is the recombinant human-derived 5HT1B protein, expressed by E. coli Cell-free , with N-10*His labeled tag. The total length of 5HT1B Protein, Human (Cell-Free, His) is 390 a.a., .

5HT1B 蛋白充当 5-羟色胺（血清素）的 G 蛋白偶联受体，并充当麦角生物碱衍生物、各种抗焦虑药和抗抑郁药以及麦角酸二乙酰胺 (LSD) 等精神活性物质的受体。配体结合后，5HT1B 会发生构象变化，通过鸟嘌呤核苷酸结合蛋白（G 蛋白）启动信号传导并调节下游效应子，例如腺苷酸环化酶，最终抑制腺苷酸环化酶活性。视紫红质抑制蛋白家族的成员在抑制 G 蛋白信号传导和激活替代信号传导途径中发挥作用。这种调节机制延伸到大脑中 5-羟色胺、多巴胺和乙酰胆碱的释放，影响神经活动、伤害性处理、疼痛感知、情绪和行为。此外，5HT1B 有助于脑动脉血管收缩，与 HTR1D 形成同二聚体和异二聚体。

Human

E. coli Cell-free

N-10*His

P28222 (M1-S390)

3351

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.