2. 重组蛋白
  3. Enzymes & Regulators
  4. Transferases (EC 2)
  5. MEK1 蛋白, Mouse (sf9)

MEK1 蛋白, Mouse (sf9)

目录号: HY-P73826
产品使用指南

MEK1 蛋白是一种双特异性激酶，在 MAP 激酶通路中发挥着至关重要的作用。MEK1 调节各种细胞过程，如生长、粘附、存活和分化，以及转录、代谢和细胞骨架重排。MEK1 蛋白, Mouse (sf9) 是重组的 MEK1 蛋白，由 Sf9 insect cells 表达，不带标签。MEK1 蛋白, Mouse (sf9) 全长 393 个氨基酸，分子量约为 ~45 kDa。

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3.  试用装只面向终端客户。

规格 是否有货
50 μg   询价  
100 μg   询价  

* Please select Quantity before adding items.

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描述

The MEK1 protein is a dual-specificity kinase that plays a crucial role in the MAP kinase pathway. MEK1 regulates various cellular processes such as growth, adhesion, survival, and differentiation, as well as transcription, metabolism, and cytoskeletal rearrangements. MEK1 Protein, Mouse (sf9) is the recombinant mouse-derived MEK1 protein, expressed by Sf9 insect cells , with tag free. The total length of MEK1 Protein, Mouse (sf9) is 393 a.a., with molecular weight of ~45 kDa.
研究背景

MEK1 蛋白是 MAP 激酶信号转导通路的关键组成部分，在将细胞外信号转变成细胞内反应方面发挥着至关重要的作用。当生长因子和细胞因子等配体与其细胞表面受体结合时，MEK1 作为 RAS-RAF1-MEK1/2-MAPK/ERK 级联的一部分被激活。MEK1 与 MAP2K2/MEK2 一起催化 ERK1 和 ERK2 激活环中苏氨酸和酪氨酸残基的双重磷酸化，从而启动下游信号传导事件。该级联调节多种生物功能，包括细胞生长、粘附、存活和分化。除了在转录和细胞骨架调节中发挥作用外，MAPK/ERK 通路还会影响过氧化物酶体增殖物激活受体 γ (PPARG)，从而促进分化和凋亡等细胞过程。此外，MEK1 参与有丝分裂期间的内体动力学和高尔基体碎裂，强调了其在协调复杂的细胞反应方面的多功能性。
种属

Mouse
表达系统

Sf9 insect cells
标签

Tag Free
蛋白编号

P31938 (N-G&P, M1-I393)
基因 ID
蛋白结构
N-term
Gly-Pro
Gly-Pro
MEK1 (M1-I393)
Accession # P31938
C-term
同用名
Dual specificity mitogen-activated protein kinase kinase 1; MAPKK 1; MEK 1; Map2k1
分子量

Approximately 45 kDa
纯度

Greater than 85% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

MEK1 Protein, Mouse (sf9) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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