PRLR 蛋白, Human (Cell-Free, His, Myc)

Prolactin receptor (PRLR) protein, as a receptor for prolactin (PRL), is an important pro-survival factor for sperm. Its key roles include inhibition of sperm capacitation by inhibiting SRC kinase activation while simultaneously stimulating AKT. PRLR Protein, Human (Cell-Free, His, Myc) is the recombinant human-derived PRLR protein, expressed by E. coli Cell-free , with N-10*His, C-Myc labeled tag. The total length of PRLR Protein, Human (Cell-Free, His, Myc) is 598 a.a., with molecular weight of 71.9 kDa.

催乳素受体 (PRLR) 蛋白是垂体前叶激素催乳素 (PRL) 的受体，是精子存活的关键因子。其关键作用包括通过抑制 SRC 激酶激活和同时刺激 AKT 来抑制精子获能。值得注意的是，异构体 4 和异构体 6 都不能转导催乳素信号传导。在与其激素配体结合后，PRLR 发生同二聚化，突出其激活状态。此外，PRLR 与 SMARCA1、GH1、CSH、NEK3 和 VAV2 发生复杂的相互作用，后两种相互作用是催乳素依赖性的。这些集体观察强调了 PRLR 的多样化和精细调节功能，揭示了其在调节细胞过程中的重要作用，特别是在激素反应和细胞生存机制领域。

Human

E. coli Cell-free

N-10*His;C-Myc

P16471 (Q25-H622)

5618

QLPPGKPEIFKCRSPNKETFTCWWRPGTDGGLPTNYSLTYHREGETLMHECPDYITGGPNSCHFGKQYTSMWRTYIMMVNATNQMGSSFSDELYVDVTYIVQPDPPLELAVEVKQPEDRKPYLWIKWSPPTLIDLKTGWFTLLYEIRLKPEKAAEWEIHFAGQQTEFKILSLHPGQKYLVQVRCKPDHGYWSAWSPATFIQIPSDFTMNDTTVWISVAVLSAVICLIIVWAVALKGYSMVTCIFPPVPGPKIKGFDAHLLEKGKSEELLSALGCQDFPPTSDYEDLLVEYLEVDDSEDQHLMSVHSKEHPSQGMKPTYLDPDTDSGRGSCDSPSLLSEKCEEPQANPSTFYDPEVIEKPENPETTHTWDPQCISMEGKIPYFHAGGSKCSTWPLPQPSQHNPRSSYHNITDVCELAVGPAGAPATLLNEAGKDALKSSQTIKSREEGKATQQREVESFHSETDQDTPWLLPQEKTPFGSAKPLDYVEIHKVNKDGALSLLPKQRENSGKPKKPGTPENNKEYAKVSGVMDNNILVLVPDPHAKNVACFEESAKEAPPSLEQNQAEKALANFTATSSKCRLQLGGLDYLDPACFTHSFH

71.9 kDa

Greater than 90% as determined by reducing SDS-PAGE.

<1 EU/μg, determined by LAL method.