2. MAPK/ERK Pathway Cell Cycle/DNA Damage Apoptosis Autophagy Metabolic Enzyme/Protease Immunology/Inflammation NF-κB
  3. Ribosomal S6 Kinase (RSK) Topoisomerase Apoptosis Autophagy Reactive Oxygen Species (ROS)
  4. RSK2/TOP2-IN-1

RSK2/TOP2-IN-1 是一种 RSK2/TOP2 双重抑制剂。RSK2/TOP2-IN-1 靶向关键的肿瘤进展酶，包括核糖体 S6 激酶 (ribosomal S6 kinase) 2 和拓扑异构酶 (topoisomerases) IIα/IIβ。RSK2/TOP2-IN-1 对所有鳞状细胞癌 (SCC) 细胞系的选择性指数均大于 2。RSK2/TOP2-IN-1 可诱导细胞凋亡 (apoptosis)、自噬 (autophagy) 和活性氧 (ROS) 的产生。RSK2/TOP2-IN-1 可用于癌症研究，如鳞状细胞癌。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

RSK2/TOP2-IN-1

RSK2/TOP2-IN-1 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

RSK2/TOP2-IN-1 相关抗体

Top Publications Citing Use of Products

查看 Ribosomal S6 Kinase (RSK) 亚型特异性产品:

查看所有亚型
p70S6K RSK2 RSK3 RSK4

查看 Topoisomerase 亚型特异性产品:

查看所有亚型
Topoisomerase Topo I Topo II

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RSK2/TOP2-IN-1 is a RSK2/TOP2 dual inhibitor. RSK2/TOP2-IN-1 targets key tumor progression enzymes including ribosomal S6 kinase 2 and topoisomerases IIα/IIβ. RSK2/TOP2-IN-1 shows selectivity index > 2 against all squamous cell carcinoma (SCC) cell lines. RSK2/TOP2-IN-1 can induce cell apoptosis, autophagy and ROS production. RSK2/TOP2-IN-1 can be used for the research of cancer, such as squamous cell carcinoma[1].

IC50 & Target[1]

RSK2

 

topoisomerase II alpha

 

topoisomerase II beta

 

体外研究
(In Vitro)

RSK2/TOP2-IN-1 (Compound 7e) (72 h) 对口腔鳞状细胞癌 (SCC-4、SCC-9、SCC-25) 细胞具有强效细胞毒性，其 IC50 值分别为 57.1、46.5 和 13.0 μM[1]。
RSK2/TOP2-IN-1 (72 h) 可抑制结直肠癌 HCT-116 细胞、肝癌 HepG2 细胞和黑色素瘤 B16-F10 细胞， IC50 值分别为 9.1、3.4 和 7.5 μM[1]。
RSK2/TOP2-IN-1 (500 μM, 24 h) 对红细胞的溶血率小于 2%[1]。
RSK2/TOP2-IN-1 (93 μM, 24 h) 可诱导 SCC-9 细胞凋亡[1]。
RSK2/TOP2-IN-1 (46.5 μM, 48 h) 可诱导 SCC-9-LC3-GFP 细胞中 LC3 阳性自噬小体的形成[1]。
RSK2/TOP2-IN-1 (93 μM, 24-72 h) 会诱导 SCC-9 细胞中活性氧的产生[1]。
RSK2/TOP2-IN-1 (2.91 μM, 72 h) 能抑制 SCC-9 细胞的迁移，伤口闭合率为 54.7%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RSK2/TOP2-IN-1 相关抗体:

Apoptosis Analysis[1]

Cell Line: SCC-9 cells
Concentration: 93 μM
Incubation Time: 24 h
Result: Activated caspase 3/7 with 78.6% positive cells.
Induced cell shrinkage and membrane blebbing.
体内研究
(In Vivo)

RSK2/TOP2-IN-1 (Compound 7e) (100-400 mg/kg，腹腔注射，单次给药) 在 C57BL/6 小鼠中未导致死亡，也未导致体重下降[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice[1]
Dosage: 100, 200 and 400 mg/kg
Administration: Intraperitoneally injection
Result: Caused no death and no body weight loss.
Had no lesions in liver, kidney, heart, or other organs in necropsy.
Had a predicted median lethal dose of 2000 mg/kg.
分子量

518.64

Formula

C29H26O5S2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

RSK2/TOP2-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RSK2/TOP2-IN-1Ribosomal S6 Kinase (RSK)TopoisomeraseApoptosisAutophagyReactive Oxygen Species (ROS)S6KRSK2TOP2ROSSCCInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
RSK2/TOP2-IN-1
目录号：
HY-178029
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z