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Results for "

chemotype

" in MCE Product Catalog:

By Targets:	Antibiotic (1) Bacterial (2) Dipeptidyl Peptidase (2) Opioid Receptor (1) Potassium Channel (1) ROR (2)
By Research Areas:	Cancer (2) Infection (2) Metabolic Disease (2) Neurological Disease (2)

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化合物筛选库

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Cat. No.	Product Name	Target	Research Area	Chemical Structure

HY-141515

BMS-986121	Opioid Receptor	Neurological Disease
BMS-986121 是 μ opioid receptor 的正变构调节剂 (PAM) 来自专利 WO2014107344。BMS-986121 是建立在一个化学支架上，代表了 μ 受体 PAMs 的一种新的化学类型。

HY-119464

MRL-871 1 篇文献验证	ROR	Cancer
MRL-871 (compound 3) 是一种有效的变构的维甲酸受体相关孤儿受体 γt (RORγt) 反向激动剂，IC₅₀ 为 264 nM。MRL-871 具有独特的异恶唑化学型，可有效减少 EL4 细胞中 IL-17a mRNA 的生成。

HY-124482

Mesembrenol	Others	Others
Mesembrenol (Chemotype c) 是一种生物碱，广泛存在于植物中。Mesembrenol 在松叶菊原料和产品的质量控制中有潜在应用。

HY-133128

FM26	ROR	Cancer
FM26 (化合物 25) 是一种有效的变构的维甲酸受体相关孤儿受体 γt (RORγt) 反向激动剂，IC₅₀ 为 264 nM。FM26 具有独特的异恶唑化学型，可有效减少 EL4 细胞中 IL-17a mRNA 的生成。

HY-139863

Antibacterial agent 62	Bacterial	Infection
Antibacterial agent 62 是一种新型氧化还原循环抗结核化合物，对生长和营养缺乏的表型耐药非生长细菌具有强大的杀菌活性。

HY-139748

ETX0462	Antibiotic Bacterial	Infection
ETX0462 是一种革兰氏阴性化学型抗生素。ETX0462 对铜绿假单胞菌以及所有其他革兰氏阴性 ESKAPE 病原体、嗜麦芽窄食单胞菌和生物威胁病原体具有有效的体外和体内活性。

HY-14806B

Teneligliptin hydrobromide hydrate 最多引用文献 6 篇文献验证 MP-513 hydrobromide hydrate	Dipeptidyl Peptidase	Metabolic Disease
氢溴酸替格列汀水合物 Teneligliptin hydrobromide hydrate 是一种有效的 DPP-4 抑制剂，竞争性抑制人血浆、大鼠血浆和重组人 DPP-4 的活性，IC₅₀ 值约为 1 nM。

HY-14806A

Teneligliptin hydrobromide 最多引用文献 6 篇文献验证 MP-513 hydrobromide	Dipeptidyl Peptidase	Metabolic Disease
Teneligliptin hydrobromide (MP-513 hydrobromide) 是一种抗高血压剂，为 β₂ 肾上腺素能受体 (β₂AR) 阻滞剂，具有抗氧化、清除自由基的活性。

HY-124424

VU0071063	Potassium Channel	Others Neurological Disease
VU0071063 是一种有效且特异的 Kir6.2/SUR1 开启剂 (EC₅₀=7.44 μM)，可用于研究 Kir6.2 /SUR1 在胰腺和大脑中的表达。VU0071063 通过诱导 β 细胞膜电位的超极化来抑制胰岛素分泌。VU0071063 化学型具有非常陡峭的构效关系。

Cat. No.	Product Name

HY-L0098V

Calcium Ion Channel Library	10,560 compounds
Calcium Ion Channel Library contains about 10,560 compounds, and designed for discovery of new Voltage-gated calcium channel blockers. Calcium ion channels are responsible for an unusually large variety of physiological functions. Calcium ions entering the cell through voltage-gated channels serve as the second messenger of electrical signaling, initiating many different cellular events. Calcium Ion Channel Library encompasses both known chemotypes and molecules based on novel scaffolds identified in their in silico studies and MedChem based scaffold hopping projects.

Calcium Ion Channel Library

10,560 compounds

Calcium Ion Channel Library contains about 10,560 compounds, and designed for discovery of new Voltage-gated calcium channel blockers. Calcium ion channels are responsible for an unusually large variety of physiological functions. Calcium ions entering the cell through voltage-gated channels serve as the second messenger of electrical signaling, initiating many different cellular events. Calcium Ion Channel Library encompasses both known chemotypes and molecules based on novel scaffolds identified in their in silico studies and MedChem based scaffold hopping projects.

HY-L0054V

Discovery Diversity Set 10	10,240 compounds
Discovery Diversity Sets (DDS) are high-quality compound libraries focused on novel chemotypes and non-trivial structures. Discovery Diversity Set 10 compose of 10,240 highly diverse compounds produced only within last three years. The Discovery Diversity Sets are highly recommended for random screening against new as well as popular targets because they are based on diverse novel scaffolds and latest building blocks. The hits discovered are expected to easily yield lead compounds.

Discovery Diversity Set 10

10,240 compounds

Discovery Diversity Sets (DDS) are high-quality compound libraries focused on novel chemotypes and non-trivial structures. Discovery Diversity Set 10 compose of 10,240 highly diverse compounds produced only within last three years. The Discovery Diversity Sets are highly recommended for random screening against new as well as popular targets because they are based on diverse novel scaffolds and latest building blocks. The hits discovered are expected to easily yield lead compounds.

HY-L0055V

Discovery Diversity Set 50	50,240 compounds
Discovery Diversity Sets (DDS) are high-quality compound libraries focused on novel chemotypes and non-trivial structures. Discovery Diversity Set 50 compose of 50,240 highly diverse compounds produced only within last three years. The two sets do not overlap and deliver a total of 60 thousand compounds. The Discovery Diversity Sets are highly recommended for random screening against new as well as popular targets because they are based on diverse novel scaffolds and latest building blocks. The hits discovered are expected to easily yield lead compounds.

Discovery Diversity Set 50

50,240 compounds

Discovery Diversity Sets (DDS) are high-quality compound libraries focused on novel chemotypes and non-trivial structures. Discovery Diversity Set 50 compose of 50,240 highly diverse compounds produced only within last three years. The two sets do not overlap and deliver a total of 60 thousand compounds. The Discovery Diversity Sets are highly recommended for random screening against new as well as popular targets because they are based on diverse novel scaffolds and latest building blocks. The hits discovered are expected to easily yield lead compounds.

HY-L0072V

Agro-like Library	10,240 compounds
A unique library composed of 10,240 compounds intended for use in agro/crop science.

HY-L0079V

Glycomimetic Library	2,470 compounds
A specially synthesized set of 2,470 compounds able to mimic glycosides and their interaction with proteins. The main emphasis of library design was made on drug-like compounds enriched with H-bond donors (possess at least two H-bond donors) and bearing nature-like Fsp3–rich scaffolds with diverse spatial orientation of H-bond donors and different 3D-shapes.

HY-L0083V

	8,960 compounds
A set of 8,960 compounds targeting alpha-helix and beta-turn domains.

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。沪(浦)应急管危经许[2021]201709(QFYS)

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