2. JAK/STAT Signaling Stem Cell/Wnt Apoptosis
  3. STAT Apoptosis Bcl-2 Family Caspase
  4. STAT3-IN-44

STAT3-IN-44 是一种强效的 STAT3 抑制剂，其 IC50 值分别为 1.84 (C6 细胞) 和 4.81 μM (A549 细胞)。STAT3-IN-44 能抑制 STAT3 的磷酸化，下调 Bcl-2 的表达，并上调 Caspase-3 的表达，从而促进晚期的细胞凋亡 (apoptosis)。STAT3-IN-44 能显著抑制肿瘤细胞的增殖和迁移。STAT3-IN-44 可用于研究诸如胶质瘤和肺癌等癌症。

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STAT3-IN-44

STAT3-IN-44 Chemical Structure

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STAT3-IN-44 相关抗体

Top Publications Citing Use of Products

查看 STAT 亚型特异性产品:

查看所有亚型
STAT3 STAT5 STAT6 STAT1

查看 Bcl-2 Family 亚型特异性产品:

查看所有亚型
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3

查看 Caspase 亚型特异性产品:

查看所有亚型
Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

STAT3-IN-44 is a potent STAT3 inhibitor with IC50s of 1.84 (C6 cells) and 4.81 μM (A549 cells). STAT3-IN-44 inhibits STAT3 phosphorylation, downregulates Bcl-2, and upregulates Caspase-3 to promote late-stage apoptosis. STAT3-IN-44 significantly suppresses tumor cell proliferation and migration. STAT3-IN-44 can be used for the study of cancers such as glioma and lung cancer[1].

IC50 & Target[1]

Caspase 3

 

Bcl-2

 

STAT3

 

体外研究
(In Vitro)

STAT3-IN-44 (Compound 18q) (10 μM, 24 h) 通过 STAT3-Bcl-2/Caspase-3 通路显著诱导了 C6 细胞凋亡[1]。
STAT3-IN-44 (2.5-10 μM, 10 days) 在浓度为 10μM 时几乎完全抑制了 C6 细胞的集落形成[1]。
STAT3-IN-44 (10 μM, 24 h) 显著抑制了 C6 细胞的迁移[1]。
STAT3-IN-44 (50 μM, 37-70℃) 显著增强了 STAT3 在 C6 细胞中的热稳定性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

STAT3-IN-44 相关抗体:

Apoptosis Analysis[1]

Cell Line: C6 cells
Concentration: 2.5, 5, 10 μM
Incubation Time: 24 h
Result: Revealed distinct apoptotic features, including chromatin condensation and apoptotic body formation.
Significantly increased the number of apoptotic cells and late apoptotic cells.

Western Blot Analysis[1]

Cell Line: C6 cells
Concentration: 2.5, 5, 10 μM
Incubation Time: 48 h
Result: Reduced the phosphorylation of STAT3, while the total STAT3 was almost unchanged.
Downregulated the expression of Bcl-2 and upregulated cleaved Caspase-3.

Cell Migration Assay [1]

Cell Line: C6 cells
Concentration: 2.5, 5, 10 μM
Incubation Time: 24 h
Result: Significantly inhibited cell migration.
分子量

546.06

Formula

C31H32ClN3O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

STAT3-IN-44 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STAT3-IN-44STATApoptosisBcl-2 FamilyCaspasePterostilbene-indole hybridsAnticancerMechanism of actionC6 cellsA549 cellsInhibitorinhibitorinhibit

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