1. Cell Cycle/DNA Damage
  2. Topoisomerase
    DNA/RNA Synthesis
  3. T-2513

T-2513 

目录号: HY-125930
产品使用指南

T-2513 是一种选择性的拓扑异构酶 I (topoisomerase I) 抑制剂。T-2513 与拓扑异构酶 I-DNA 复合物共价结合并使其稳定,且抑制 DNA 复制和 RNA 合成,最终导致细胞死亡。

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T-2513 Chemical Structure

T-2513 Chemical Structure

CAS No. : 288247-87-0

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Description

T-2513 is a selective topoisomerase I inhibitor. T-2513 binds covalently to and stabilizes the topoisomerase I-DNA complex and inhibits DNA replication and RNA synthesis, ultimately leading to cell death[1].

IC50 & Target[1]

Topoisomerase I

 

In Vitro

SN-38 is the metabolite of T-2513[1].
T-2513 has a broad cytotoxicity against a range of human tumor cell lines[2].

Cell Cytotoxicity Assay[2]

Cell Line: WiDr, HT-29, SK-BR-3, MKN-1, SK-LU-1, LX-1, KB, and HeLaS3 cells
Concentration: 15.1-111.5 ng/mL
Incubation Time: 24 hours
Result: Exhibited cytotoxicity against a panel of human tumor cell lines with GI50s of 32.1, 97.6, 38.6, 15.6, 111.5, 15.1, 34.0, and 50.9 ng/mL for WiDr, HT-29, SK-BR-3, MKN-1, SK-LU-1, LX-1, KB, and HeLaS3 cells, respectively.
In Vivo

T-2513 (1-100 mg/kg) shows Antitumor Activity against Walker-256 carcinoma[2].

Animal Model: Rats bearing Walker-256 carcinoma[2]
Dosage: 1, 10, and 100 mg/kg
Administration:
Result: The ED50 was 23 mg/kg.
Molecular Weight

449.50

Formula

C₂₅H₂₇N₃O₅

CAS No.

288247-87-0

SMILES

O=C1[C@](O)(CC)C2=C(CO1)C(N3CC4=C(CC)C5=CC(OCCCN)=CC=C5N=C4C3=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

T-2513T2513T 2513TopoisomeraseDNA/RNA SynthesistopoisomeraseDNAreplicationRNAsynthesisT-0128SN-38Inhibitorinhibitorinhibit

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T-2513
目录号:
HY-125930
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