2. Apoptosis
  3. TNF Receptor
  4. Tecaginlimab

Tecaginlimab  (Synonyms: BNT-312; DuoBody-CD40x-4-1BB; GEN1042)

目录号: HY-P99572

摩尔计算器

Tecaginlimab (BNT-312) 是一种 Fc 惰性双特异性抗体，用于 CD40 和 4-1BB 的双重靶向和条件刺激。Tecaginlimab 可以增强肿瘤特异性免疫的启动和再激活。

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Tecaginlimab Chemical Structure

Tecaginlimab Chemical Structure

CAS No. : 2253891-70-0

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Customer Review

Tecaginlimab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tecaginlimab (BNT-312) is a Fc-inert bispecific antibody for dual targeting and conditional stimulation of CD40 and 4-1BB. Tecaginlimab can enhance priming and reactivation of tumor-specific immunity[1].

IC50 & Target[1]

CD40

 

4-1BB

 

体外研究
(In Vitro)

Tecaginlimab 结合重组人 CD40 和 4-1BB，亲和力分别为 1.0 nM 和 0.17 nM[1]。
Tecaginlimab (0.001-1 µg/mL; 5 d) 在体外诱导树突状细胞 (DC) 成熟[1]。
Tecaginlimab (0.2 µg/mL; 10-15 d) 在体外增强 T 细胞活化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tecaginlimab 相关抗体:
体内研究
(In Vivo)

Tecaginlimab (0.0008-0.2 µg/mL; 4 d) 增强肿瘤浸润淋巴细胞的扩增[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
CAS 号
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tecaginlimab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tecaginlimab2253891-70-0BNT-312 DuoBody-CD40x-4-1BB GEN1042BNT312BNT 312GEN1042GEN 1042GEN-1042TNF ReceptorTumor Necrosis Factor ReceptorTNFRFc-inertCD404-1BBimmunityInhibitorinhibitorinhibit

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