1. Cell Cycle/DNA Damage
  2. PPAR
  3. Tesaglitazar

Tesaglitazar 

目录号: HY-17444 纯度: 96.24%
产品使用指南

Tesaglitazar 是一种过氧物酶体 PPAR alpha/gamma 受体的双重激动剂,对 PPARγ 的作用比 PPARα 强,对大鼠和人类 PPARα 作用的 EC50 分别为 13.4 μM 和 3.6 μM,对大鼠和人类 PPARγ 作用的 EC50 为 0.2 μM。Tesaglitazar 在大鼠皮下组织中,诱导间质间充质细胞 DNA 合成和纤维肉瘤形成。

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Tesaglitazar Chemical Structure

Tesaglitazar Chemical Structure

CAS No. : 251565-85-2

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Description

Tesaglitazar is a dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist that is more potent on PPARγ than on PPARα, with EC50s of 13.4 μM and 3.6 μM for rat PPARα and human PPARα, respectively, and approximately 0.2 μM for both rat and human PPARγ. Tesaglitazar induces interstitial mesenchymal cell DNA synthesis and fibrosarcomas in subcutaneous tissues in rats[1].

IC50 & Target

EC50: 13.4 μM (rat PPARα), 3.6 μM (human PPARα), 0.2 μM (PPARγ)[1]

Clinical Trial
Molecular Weight

408.47

Formula

C₂₀H₂₄O₇S

CAS No.

251565-85-2

SMILES

O=C(O)[C@@H](OCC)CC1=CC=C(OCCC2=CC=C(OS(=O)(C)=O)C=C2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
References
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Keywords:

TesaglitazarPPARPeroxisome proliferator-activated receptorsInhibitorinhibitorinhibit

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产品名称:
Tesaglitazar
目录号:
HY-17444
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