2. GPCR/G Protein Neuronal Signaling
  3. Opioid Receptor
  4. U-69593

U-69593 是一种有效且选择性的 κ1阿片受体 激动剂。U-69593 减弱成瘾剂诱导的大鼠行为敏化作用。U-69593 可减轻小鼠的焦虑并增强自发交替记忆。U-69593 降低腹侧纹状体中多巴胺和谷氨酸的钙依赖性透析液水平 [4]。

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U-69593 Chemical Structure

U-69593 Chemical Structure

CAS No. : 96744-75-1

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规格 价格 是否有货 数量
1 mg ￥2320
In-stock
5 mg ￥5800
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U-69593 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

U-69593 is a potent and selective κ1-opioid receptor agonist[1]. U-69593 attenuates addictive agent-induced behavioral sensitization in the rat[2]. U-69593 reduces anxiety and enhances spontaneous alternation memory in mice[3]. U-69593 reduces calcium-dependent dialysate levels of dopamine and glutamate in the ventral striatum[4].

IC50 & Target

κ Opioid Receptor/KOR

 

体内研究
(In Vivo)

U-69593 (0.16 mg/kg；sc) 减轻成瘾剂诱导的大鼠行为敏化[2]。
U-69593 (1、10、25 nmol/μL；显微注射) 减少小鼠的焦虑并增强自发交替记忆[3]。
U-69593 (0.32 mg/kg；sc) 降低急性苯丙胺诱发的行为和钙依赖性透析液中多巴胺和腹侧纹状体中的谷氨酸[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rat[2]
Dosage: 0.16 mg/kg
Administration: S.c. (an acute injection of cocaine (20 mg/kg i.p.))
Result: Attenuated the acute and chronic effects of cocaine on locomotor activity and stereotypy.
Animal Model: CD-1 mice[3]
Dosage: 1, 10, 25 nmol/µL
Administration: Microinjection (in the infralimbic cortex (IL)), once every week, 2 weeks
Result: Dose-dependently prolonged transfer-latency (T-L) and produced a dose-dependent anxiolytic behavioural profile, and after 24 h, the mouse were observed small but detectable carry-over effects. In week 2, U-69593 dose-dependently prolonged T/L and produced an anxiolytic behavioural profile in the first EPM (elevated plus-maze) trial, but observed a robust anxiolytic behavioural profile.
Animal Model: 280-350 g, male Wistar rats[4]
Dosage: 0.32 mg/kg
Administration: S.c. (followed 15 min later by an injection of amphetamine (2.5 mg/kg i.p.))
Result: Significantly reduced the amphetamine-stimulated increase in dialysate dopamine levels and blocked the ability of amphetamine to evoke an increase in dialysate glutamate levels.
分子量

356.50

Formula

C22H32N2O2
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥99.0%

COA (171 KB)

产品使用指南 (1538 KB)
参考文献

U-69593 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

U-6959396744-75-1U69593U 69593Opioid ReceptorSelectiveinfralimbic cortexanxietyspontaneous alternation memorydopamineglutamateInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-12363
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