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  2. Isotope-Labeled Compounds COX Endogenous Metabolite
  3. Valdecoxib-d3

Valdecoxib-d3  (Synonyms: SC 65872-d3)

目录号: HY-15762S
产品使用指南

Valdecoxib-d3 是 Valdecoxib 的氘代物。Valdecoxib 是一种高效的,可口服的,选择性的 COX-2 抑制剂,对 COX-2COX-1IC50 值分别为 5 nM 和 140 μM,可用于关节炎和疼痛的研究。

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Valdecoxib-d<sub>3</sub> Chemical Structure

Valdecoxib-d3 Chemical Structure

CAS No. : 1219794-90-7

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生物活性

Valdecoxib-d3 is the deuterium labeled Valdecoxib. Valdecoxib is a highly potent and selective inhibitor of COX-2, with IC50s of 5 nM and 140 μM for COX-2 and COX-1, respeceively. Valdecoxib can be used in the research of arthritis and pain[1][2].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

317.38

Formula

C16H11D3N2O3S

CAS 号
中文名称

伐地考昔 d3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Valdecoxib-d3
目录号:
HY-15762S
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