2. Immunology/Inflammation
  3. Interleukin Related
  4. Vobarilizumab

Vobarilizumab  (Synonyms: ALX-0061)

目录号: HY-P99385 纯度: 97.36%
COA

摩尔计算器

Vobarilizumab (ALX-0061) 是一种抗 IL-6R 单克隆抗体 (mAb) (Kd: 0.19 pM)。Vobarilizumab 由一个抗 IL-6R 结构域和一个抗人血清白蛋白结构域组成。Vobarilizumab 可用于炎症性自身免疫性疾病的研究，如类风湿性关节炎。

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Vobarilizumab Chemical Structure

Vobarilizumab Chemical Structure

CAS No. : 1628814-88-9

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1 mg ￥3200
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Vobarilizumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Vobarilizumab (ALX-0061) is an anti-IL-6R monoclonal antibody (mAb) (Kd: 0.19 pM). Vobarilizumab consists of an anti-IL-6R domain and an anti-human serum albumin domain. Vobarilizumab can be used in the research of inflammatory autoimmune diseases, such as rheumatoid arthritis[1][2][3].

体外研究
(In Vitro)

Vobarilizumab 显示出对 sIL-6R 的优先结合亲和力 (与 mIL-6R 相比) [2]。
Vobarilizumab (0-10 nM) 阻断重组 hIL-6 与重组 hsIL-6R 的相互作用[3]。
Vobarilizumab (0-100 nM) 可抑制 TF-1 细胞的增殖[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Vobarilizumab 相关抗体:
体内研究
(In Vivo)

Vobarilizumab (0.4-10 mg/kg，静脉注射) 抑制食蟹猴中 hIL-6 诱导的炎症[3]。
Vobarilizumab (0.4-10 mg/kg，静脉注射) 通过与食蟹猴的血清白蛋白结合显示出长期暴露[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: hIL-6-induced inflammation in cynomolgus monkey[3]
Dosage: 0.4 mg/kg, 2 mg/kg, or 10 mg/kg
Administration: Intravenous injection (i.v.)
Result: Inhibited the acute phase response parameters: plasma levels of C-reactive protein (CRP), fibrinogen and platelets.
Animal Model: Cynomolgus monkeys[3]
Dosage: 0.4 mg/kg, 2 mg/kg, or 10 mg/kg
Administration: Intravenous injection (i.v.)
Result: Pharmacokinetic parameters of Vobarilizumab
dose (mg/kg) T1/2 dominant (day) AUCinf (μg/day/mL) CL (mL/day/kg) Vss (mL/kg)
0.4 (i.v.) 1.73 16.3 24.8 42.8
2 (i.v.) 5.0 193 10.4 53.7
10 (i.v.) 6.61 1136 9 82.7
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Vobarilizumab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vobarilizumab1628814-88-9ALX-0061ALX0061ALX 0061Interleukin RelatedILRheumatoid arthritisRATF-1 cellhIL-6inflammationInhibitorinhibitorinhibit

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