2. PI3K/Akt/mTOR
  3. PI3K
  4. WXM-1-170

WXM-1-170 (compound 10) 是 Indisulam (HY-13650) 衍生物，可抑制胃癌细胞的迁移。WXM-1-170 减弱PI3K/AKT/GSK-3β/β-catenin 信号通路。

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WXM-1-170 Chemical Structure

WXM-1-170 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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Customer Review

WXM-1-170 相关抗体

Top Publications Citing Use of Products

查看 PI3K 亚型特异性产品:

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PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

WXM-1-170 (compound 10) is a Indisulam (HY-13650) derivative,and inhibits the migration of gastric cancer cells. WXM-1-170 attenuates PI3K/AKT/GSK-3β/β-catenin signaling pathway[1].

体外研究
(In Vitro)

WXM-1-170 (0.0001-100 µM, 48h) 抑制 AGS 细胞生长, IC50值为 24.75 μM[1]。
WXM-1-170 (10 µM, 48 and 72 h) 在 AGS 和 MGC803 细胞中显示出抗迁移活性[1]。
WXM-1-170 (10 µM, 48 h) 在 AGS 和 MGC803 细胞中上调 E-cadherin，下调 N-cadherin 和 vimentin的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

WXM-1-170 相关抗体:

Cell Viability Assay[1]

Cell Line: AGS cells
Concentration: 0.0001-100 µM
Incubation Time: 48 h
Result: Inhibited the cell growth of AGS cells with the IC50 of 34.68 μM.

Cell Migration Assay [1]

Cell Line: AGS and MGC803 cells
Concentration: 10 µM
Incubation Time: 48 and 72 h
Result: Showed anti-migration activity in AGS and MGC803 cells

Western Blot Analysis[1]

Cell Line: AGS and MGC803 cells
Concentration: 10 µM
Incubation Time: 48 h
Result: Upregulated E-cadherin and downregulated N-cadherin and vimentin in AGS and MGC803 cells.
分子量

388.83

Formula

C17H13ClN4O3S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

WXM-1-170 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

WXM-1-170PI3KPhosphoinositide 3-kinaseAGSindisulam derivativesInhibitory effectMigrationMGC803Inhibitorinhibitorinhibit

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产品名称：
WXM-1-170
目录号：
HY-158017
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