2. Cell Cycle/DNA Damage
  3. CDK
  4. XL413 hydrochloride

XL413 hydrochloride  (Synonyms: BMS-863233 hydrochloride)

目录号: HY-15260C
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摩尔计算器

XL413 (BMS-863233) hydrochloride 是一种口服有效的选择性 CDC7 抑制剂 (IC50=3.4 nM)。XL413 hydrochloride 具有良好的药代动力学特征，并在啮齿动物模型中显著抑制肿瘤生长。XL413 hydrochloride 可用于癌症的研究。

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XL413 hydrochloride Chemical Structure

XL413 hydrochloride Chemical Structure

CAS No. : 1169562-71-3

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XL413 hydrochloride 的其他形式现货产品:

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XL413 hydrochloride 相关抗体

Top Publications Citing Use of Products

    XL413 hydrochloride purchased from MCE. Usage Cited in: Am J Physiol Lung Cell Mol Physiol. 2018 Sep 1;315(3):L360-L370.  [Abstract]

    Representative Western blot for Endo180 expression in U937 cells treated overnight with XL413.

    查看 CDK 亚型特异性产品:

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    CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    XL413 (BMS-863233) hydrochloride is an orally active and selective CDC7 inhibitor (IC50=3.4 nM). XL413 hydrochloride has favorable pharmacokinetic profiles and significantly inhibits tumor growth in rodent models. XL413 hydrochloride can be used in cancer research[1].

    IC50 & Target[1]

    Cdc7

    3.4 nM (IC50)

    Formula

    C14H12ClN3O2.xHCl
    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    XL413 hydrochloride 相关分类

    • 摩尔计算器

    • 稀释计算器

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    XL4131169562-71-3BMS-863233XL 413XL-413BMS863233BMS 863233CDKCyclin dependent kinasecancertumorInhibitorinhibitorinhibit

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