2. Immunology/Inflammation
  3. Complement System
  4. Zilucoplan

Zilucoplan  (Synonyms: RA101495; RA3193)

目录号: HY-P3502 纯度: 95.33%
COA 产品使用指南

摩尔计算器

Zilucoplan (RA101495) 是一种 15 个氨基酸的大环肽，是一种有效的补体成分 5 (C5) 抑制剂。Zilucoplan 可用于免疫介导的坏死性肌病 (IMNM) 研究。

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Zilucoplan Chemical Structure

Zilucoplan Chemical Structure

CAS No. : 1841136-73-9

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规格 价格 是否有货 数量
1 mg ￥5500
In-stock
5 mg   询价  
10 mg   询价  

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Customer Review

Other Forms of Zilucoplan:

Zilucoplan 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Zilucoplan (RA101495), a 15-amino acid macrocyclic peptide, is a potent complement component 5 (C5) inhibitor. Zilucoplan can be used in research of immune-mediated necrotising myopathy (IMNM)[1][2].

体外研究
(In Vitro)

Zilucoplan (RA101495; 1-1000 nM; 30 min) inhibit Lipopolysaccharides-induced increase in C5a plasma levels in human whole blood with an IC50 value of 474.5 pM. Zilucoplan has a 65.7% reduction in C5a plasma levels observed at a concentration of 1 nM[2].
Zilucoplan bins to complement component 5 (C5) and blocks the downstream assembly of the membrane attack complex (MAC; C5b-9) by inhibiting the cleavage of C5 by the C5 convertase into C5a and C5b and binding to preformed C5b to sterically block interaction with C6, thereby inhibiting the formation of membrane pores and subsequent cell death[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Zilucoplan 相关抗体:
体内研究
(In Vivo)

Zilucoplan (RA101495; 10 mg/kg; S.C.; daily, for 6 d) prevents the development of immune-mediated necrotising myopathy (IMNM) in C5-deficient mice supplemented with human complement[1].
Zilucoplan (10 mg/kg; S.C.; daily, for 6 d) has protection on myopathy prevention in C57BL/6 mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/10SnJ C5-deficient (C5def) mice with anti-HMGCR+ IMNM IgG xenografts[1]
Dosage: 10 mg/kg
Administration: Subcutaneous injection; daily, for 6 days
Result: Prevented muscle strength loss in C5def mice with less complement deposition on myofibres and consequently less necrosis/regeneration.
Animal Model: C57BL/6 mice with anti-HMGCR+ IMNM IgG xenografts[1]
Dosage: 10 mg/kg
Administration: Subcutaneous injection; daily, for 6 days
Result: Prevented muscle weakness and reduced regenerated myofibres.
Decreased necrotic cells as well as regenerating cells expressing foetal myosin.
Clinical Trial
分子量

3562.18

Formula

C172H278N24O55
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 100 mg/mL (28.07 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.2807 mL 1.4036 mL 2.8073 mL
5 mM 0.0561 mL 0.2807 mL 0.5615 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Zilucoplan 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.2807 mL 1.4036 mL 2.8073 mL 7.0182 mL
5 mM 0.0561 mL 0.2807 mL 0.5615 mL 1.4036 mL
10 mM 0.0281 mL 0.1404 mL 0.2807 mL 0.7018 mL
15 mM 0.0187 mL 0.0936 mL 0.1872 mL 0.4679 mL
20 mM 0.0140 mL 0.0702 mL 0.1404 mL 0.3509 mL
25 mM 0.0112 mL 0.0561 mL 0.1123 mL 0.2807 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zilucoplan1841136-73-9RA101495 RA3193RA 101495RA-101495RA3193RA 3193RA-3193Complement Systemacid macrocyclic peptideimmune-mediated necrotising myopathyC5a plasmamuscle weaknesscomplement depositionInhibitorinhibitorinhibit

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