2. Membrane Transporter/Ion Channel Neuronal Signaling Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor
  3. iGluR LXR
  4. 24-Hydroxycholesterol

24-Hydroxycholesterol  (Synonyms: 24-羟基胆固醇)

目录号: HY-N2370 纯度: ≥98.0%
COA 产品使用指南

摩尔计算器

24-Hydroxycholesterol 是一种天然的固醇类物质，是n-甲基-d-天门冬氨酸受体 (NMDA) 和转录因子 LXR 的激活剂。

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24-Hydroxycholesterol Chemical Structure

24-Hydroxycholesterol Chemical Structure

CAS No. : 30271-38-6

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规格 价格 是否有货 数量
2 mg ￥1350
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5 mg ￥2700
In-stock
10 mg ￥4185
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Other Forms of 24-Hydroxycholesterol:

24-Hydroxycholesterol 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

24-Hydroxycholesterol is a natural sterol, which serves as a positive allosteric modulator of N-Methyl-d-Aspartate (NMDA) receptorsR, and a potent activator of the transcription factors LXR.

IC50 & Target

NMDA Receptor

 

体外研究
(In Vitro)

24S-hydroxycholesterol oxysterol-generating enzyme Cyp46a1 is overexpressed during the angiogenic switch in rat insulin promoter 1-T-antigen 2 (RIP1-Tag2) pNET formation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

24-Hydroxycholesterol 相关抗体:
体内研究
(In Vivo)

Hypoxia inducible factor-1a (HIF-1α) controls the overexpression of the enzyme Cyp46a1, which generates the oxysterol 24-hydroxycholesterol in a pancreatic neuroendocrine tumor (pNET) model commonly used to study neoangiogenesis. The activation of the HIF-1α-24S-HC axis ultimately leads to the induction of the angiogenic switch through the positioning of proangiogenic neutrophils in proximity to Cyp46a1+ islets[1]. 24-hydroxycholesterol levels are increased at 2-4 months in the untreated 5XFAD mouse brain and then became similar to those in the B6SJL mouse brain[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

402.65

Formula

C27H46O2
CAS 号
性状

固体

颜色

White to off-white

中文名称

24-羟基胆固醇
结构分类
初始来源

brain
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥99.0%

COA (264 KB) 元素分析报告 (210 KB)

产品使用指南 (1538 KB)
参考文献

24-Hydroxycholesterol 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

24-Hydroxycholesterol30271-38-624-羟基胆固醇iGluRLXRIonotropic glutamate receptorsLiver X receptorInhibitorinhibitorinhibit

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