2. Metabolic Enzyme/Protease
  3. Phosphatase
  4. 6,7-Dichloroquinoline-5,8-dione

6,7-Dichloroquinoline-5,8-dione 

目录号: HY-W102931 纯度: 98.26%
COA 产品使用指南 技术支持

6,7-Dichloroquinoline-5,8-dione (compound DA3002) 是一种有效的 CDC25B2 抑制剂，IC50 值为 4.6 µM。6,7-Dichloroquinoline-5,8-dione 具有用于癌症研究的潜力。

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6,7-Dichloroquinoline-5,8-dione

6,7-Dichloroquinoline-5,8-dione Chemical Structure

CAS No. : 6541-19-1

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规格 价格 是否有货 数量
100 mg ￥787
In-stock
250 mg ￥1566
In-stock
500 mg ￥2501
In-stock
1 g ￥3993
In-stock
5 g 现货 询价
10 g 现货 询价
50 g   询价  

* Please select Quantity before adding items.

6,7-Dichloroquinoline-5,8-dione 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

6,7-Dichloroquinoline-5,8-dione (compound DA3002) is a potent CDC25B2 inhibitor with an IC50 value of 4.6 µM. 6,7-Dichloroquinoline-5,8-dione has the potential for the research of cancer[1].

IC50 & Target

IC50: 4.6 µM (CDC25B2)[1]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
C32 IC50
22.72 μM
Compound: 1
Cytotoxicity against human C32 cells harboring low levels of NQO1 after 72 hrs by WST1 assay
Cytotoxicity against human C32 cells harboring low levels of NQO1 after 72 hrs by WST1 assay
[PMID: 28006669]
CEM-SS CC50
1 μM
Compound: 81047
Cytotoxicity in human CEM-SS cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity in human CEM-SS cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 27663546]
HEK-293T CC50
17 μM
Compound: 81047
Cytotoxicity in HEK293T cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity in HEK293T cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 27663546]
HFF-1 IC50
15.66 μM
Compound: 1
Cytotoxicity against HFF1 after 72 hrs by WST1 assay
Cytotoxicity against HFF1 after 72 hrs by WST1 assay
[PMID: 28006669]
HL-60 IC50
31.8 μM
Compound: 7a
Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay
Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay
[PMID: 20363637]
MCF7 IC50
22.5 μM
Compound: 1
Cytotoxicity against human MCF7 cells harboring high levels of NQO1 after 72 hrs by WST1 assay
Cytotoxicity against human MCF7 cells harboring high levels of NQO1 after 72 hrs by WST1 assay
[PMID: 28006669]
MDA-MB-231 IC50
24.96 μM
Compound: 1
Cytotoxicity against human MDA-MB-231 cells harboring undetectable levels of NQO1 after 72 hrs by WST1 assay
Cytotoxicity against human MDA-MB-231 cells harboring undetectable levels of NQO1 after 72 hrs by WST1 assay
[PMID: 28006669]
MT4 CC50
2 μM
Compound: 81047
Cytotoxicity in human MT4 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity in human MT4 cells assessed as reduction in cell viability after 48 hrs by MTT assay
[PMID: 27663546]
Neutrophil IC50
1.3 μM
Compound: 7a
Antiinflammatory activity in human neutrophils assessed as inhibition of PMA-induced superoxide production after 20 mins by WST1 assay
Antiinflammatory activity in human neutrophils assessed as inhibition of PMA-induced superoxide production after 20 mins by WST1 assay
[PMID: 20363637]
SNB-19 IC50
26.1 μM
Compound: 1
Cytotoxicity against human SNB19 cells harboring undetectable levels of NQO1 after 72 hrs by WST1 assay
Cytotoxicity against human SNB19 cells harboring undetectable levels of NQO1 after 72 hrs by WST1 assay
[PMID: 28006669]
T-cell IC50
32.9 μM
Compound: 7a
Antiproliferative activity against human T cells after 48 hrs by MTT assay
Antiproliferative activity against human T cells after 48 hrs by MTT assay
[PMID: 20363637]
分子量

228.03

Formula

C9H3Cl2NO2
CAS 号
性状

固体

颜色

Light green to green

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验： 

DMSO 中的溶解度 : 25 mg/mL (109.63 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.3854 mL 21.9269 mL 43.8539 mL
5 mM 0.8771 mL 4.3854 mL 8.7708 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用，-20°C储存时，请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

6,7-Dichloroquinoline-5,8-dione 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用，-20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.3854 mL 21.9269 mL 43.8539 mL 109.6347 mL
5 mM 0.8771 mL 4.3854 mL 8.7708 mL 21.9269 mL
10 mM 0.4385 mL 2.1927 mL 4.3854 mL 10.9635 mL
15 mM 0.2924 mL 1.4618 mL 2.9236 mL 7.3090 mL
20 mM 0.2193 mL 1.0963 mL 2.1927 mL 5.4817 mL
25 mM 0.1754 mL 0.8771 mL 1.7542 mL 4.3854 mL
30 mM 0.1462 mL 0.7309 mL 1.4618 mL 3.6545 mL
40 mM 0.1096 mL 0.5482 mL 1.0963 mL 2.7409 mL
50 mM 0.0877 mL 0.4385 mL 0.8771 mL 2.1927 mL
60 mM 0.0731 mL 0.3654 mL 0.7309 mL 1.8272 mL
80 mM 0.0548 mL 0.2741 mL 0.5482 mL 1.3704 mL
100 mM 0.0439 mL 0.2193 mL 0.4385 mL 1.0963 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

6,7-Dichloroquinoline-5,8-dione6541-19-1Phosphatasedual specificity protein phosphatase Cdc25cancerInhibitorinhibitorinhibit

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