2. Apoptosis
  3. Apoptosis
  4. AMXT-1501 tetrahydrochloride

AMXT-1501 tetrahydrochloride 

目录号: HY-124617A 纯度: ≥98.0%
COA 产品使用指南

摩尔计算器

AMXT-1501 tetrahydrochloride 是一种具有口服活性的多胺转运系统 (polyamine transport) 抑制剂。AMXT-1501 可阻断免疫活性小鼠中的肿瘤生长，但不能阻断缺乏 T 细胞无胸腺裸鼠中的肿瘤生长。DFMO 和 AMXT-1501 联合诱导 caspase-3 介导的 NB 细胞凋亡。

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AMXT-1501 tetrahydrochloride Chemical Structure

AMXT-1501 tetrahydrochloride Chemical Structure

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规格 价格 是否有货 数量
1 mg ￥2200
In-stock
5 mg ￥5500
In-stock
10 mg ￥8500
In-stock
50 mg   询价  
100 mg   询价  

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Customer Review

Other Forms of AMXT-1501 tetrahydrochloride:

AMXT-1501 tetrahydrochloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AMXT-1501 tetrahydrochloride is an orally active polyamine transport inhibitor. AMXT1501 blocks tumor growth in immunocompetent mice but not in athymic nude mice lacking T cells[1]. Combination of DFMO and AMXT‐1501 induces caspase‐3 mediated apoptosis in NB cell lines[2].

IC50 & Target

Polyamine transport[1]
体外研究
(In Vitro)

AMXT-1501 tetrahydrochloride (0.39-50 µM; 48 hours) treatment exhibits cytotoxicity against this panel of NB cell lines (BE(2)-C, SMS-KCNR and SH-SY5Y cells), with IC50 values of 17.72 µM for SMS-KCNR, 17.69 µM for BE(2)-C, and 14.13 µM for SH-SY5Y[2].
BE(2)‐C, SMS‐KCNR and SH‐SY5Y cells are exposed to AMXT-1501 tetrahydrochloride (2.5 µM) and DFMO (2.5 mM) alone or in combination (AMXT-1501 tetrahydrochloride 2.5 µM + DFMO 2.5 mM). After 96 hours exposure to AMXT-1501 tetrahydrochloride or DFMO does not significantly alter the level of noncleaved PARP, cleaved PARP and cleaved caspase 3, whereas cells treated with the combination of AMXT-1501 tetrahydrochloride with DFMO decrease the amount of noncleaved PARP and increase the amount of cleaved PARP and cleaved caspase 3[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AMXT-1501 tetrahydrochloride 相关抗体:

Cell Viability Assay[2]

Cell Line: BE(2)‐C, SMS‐KCNR and SH‐SY5Y cells
Concentration: 0.39 µM, 1 µM, 3.1 µM, 10 µM, 31 µM, 50 µM
Incubation Time: 48 hours
Result: AMXT-1501 tetrahydrochloride exhibited cytotoxicity against this panel of NB cell lines.

Western Blot Analysis[2]

Cell Line: BE(2)‐C, SMS‐KCNR and SH‐SY5Y cells
Concentration: 2.5 µM
Incubation Time: 72 hours
Result: Combination treatment with DFMO decreased the amount of noncleaved PARP and increased the amount of cleaved PARP and cleaved caspase 3 in all three cell lines.
体内研究
(In Vivo)

AMXT-1501 tetrahydrochloride (3 mg/kg; subcutaneous injection; every day; 28 days) alone is sufficient to delay EAE onset moderately,but fails to protect animals from reaching the endpoint. However, the combination of DFMO and AMXT-1501 tetrahydrochloride are sufficient to deplete T cell polyamine pool, and consequently suppress T cell proliferation and effector function in vivo[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (WT) and ODC knockout strain (ODC cKO) mice bearing experimental autoimmune encephalomyelitis (EAE) model [3]
Dosage: 3 mg/kg
Administration: Subcutaneous injection; every day; 28 days
Result: Displayed a delayed disease onset initially, but eventually proceeded with pathologic development and reached the endpoint.
Clinical Trial
分子量

714.77

Formula

C32H72Cl4N6O2
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
In Vitro: 

H2O 中的溶解度 : 83.33 mg/mL (116.58 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.3991 mL 6.9953 mL 13.9905 mL
5 mM 0.2798 mL 1.3991 mL 2.7981 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

In Vivo:

以下溶解方案，请直接配置工作液。建议现用现配，在短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比； 如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。

  • 方案 一

    请依序添加每种溶剂： PBS

    Solubility: 50 mg/mL (69.95 mM); 澄清溶液; 超声助溶

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: ≥98.0%

COA (255 KB) HNMR (295 KB)

产品使用指南 (1538 KB)
参考文献

AMXT-1501 tetrahydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.3991 mL 6.9953 mL 13.9905 mL 34.9763 mL
5 mM 0.2798 mL 1.3991 mL 2.7981 mL 6.9953 mL
10 mM 0.1399 mL 0.6995 mL 1.3991 mL 3.4976 mL
15 mM 0.0933 mL 0.4664 mL 0.9327 mL 2.3318 mL
20 mM 0.0700 mL 0.3498 mL 0.6995 mL 1.7488 mL
25 mM 0.0560 mL 0.2798 mL 0.5596 mL 1.3991 mL
30 mM 0.0466 mL 0.2332 mL 0.4664 mL 1.1659 mL
40 mM 0.0350 mL 0.1749 mL 0.3498 mL 0.8744 mL
50 mM 0.0280 mL 0.1399 mL 0.2798 mL 0.6995 mL
60 mM 0.0233 mL 0.1166 mL 0.2332 mL 0.5829 mL
80 mM 0.0175 mL 0.0874 mL 0.1749 mL 0.4372 mL
100 mM 0.0140 mL 0.0700 mL 0.1399 mL 0.3498 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AMXT-1501 tetrahydrochlorideApoptosispolyaminetumorInhibitorinhibitorinhibit

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