1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. BMH-21

BMH-21是一种首创的 DNA 嵌入剂 (DNA intercalator),可抑制 RNA 聚合酶 I (Pol I) 转录。BMH-21 具有抗癌活性。

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BMH-21 Chemical Structure

BMH-21 Chemical Structure

CAS No. : 896705-16-1

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1 mg ¥203
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5 mg ¥406
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50 mg ¥2000
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100 mg ¥3500
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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

BMH-21 is a first-in-class DNA intercalator which inhibits RNA polymerase I (Pol I) transcription. BMH-21 possesses anticancer activity[1][2].

IC50 & Target
体外研究
(In Vitro)

BMH-21 binds ribosomal DNA and inhibits Pol I transcription[1].
? BMH-21 inhibits RNA polymerase I independent of DNA damage response[1].
? BMH-21 intercalates into double strand (ds) DNA and has binding preference towards GC-rich DNA sequences[1].
? BMH-21 (1 μM; 3 hours) acts in a DNA damage independent manner to activate nucleolar stress and RPA194 degradation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: U2OS cells
Concentration: 0 μM, 0.1 μM , 1 μM, 10 μM
Incubation Time: 48 hours
Result: Decreased the viability of cells at concentrations that activated the DNA damage response.

Western Blot Analysis[1]

Cell Line: A375 cells
Concentration: 1 μM
Incubation Time: 3 hours
Result: Degraded RPA194 with blocked ATM and DNA-PKcs activity.
体内研究
(In Vivo)

BMH-21 (50 mg/kg; i.p.; daily; for 6 days) inhibits HCT116 colon cancer tumor growth in vivo[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-week old athymic NCr nu/nu mice, with HCT116 colorectal carcinoma xenograft[2]
Dosage: 50 mg/kg
Administration: Intraperitoneal injection, daily, for 6 days
Result: Significantly inhibited HCT116 colon cancer tumor growth.
分子量

360.41

Formula

C21H20N4O2

CAS 号
性状

固体

颜色

Yellow to orange

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 1 mg/mL (2.77 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7746 mL 13.8731 mL 27.7462 mL
5 mM --- --- ---
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 2 years; -20°C, 1 year。-80°C储存时,请在2年内使用, -20°C储存时,请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7746 mL 13.8731 mL 27.7462 mL 69.3654 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
BMH-21
目录号:
HY-12484
需求量: