2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. Bemesetron

Bemesetron  (Synonyms: MDL 72222)

目录号: HY-B1541 纯度: ≥99.0%
COA 产品使用指南

摩尔计算器

Bemesetron (MDL 72222) 是一种选择性 5-HT3 受体拮抗剂，IC50 为 0.33 nM 。具有神经保护作用。

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Bemesetron Chemical Structure

Bemesetron Chemical Structure

CAS No. : 40796-97-2

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规格 价格 是否有货 数量
1 mg ￥300
In-stock
5 mg ￥750
In-stock
10 mg ￥1200
In-stock
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100 mg   询价  

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Customer Review

Bemesetron 相关抗体

Top Publications Citing Use of Products

查看 5-HT Receptor 亚型特异性产品:

查看所有亚型
5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Bemesetron (MDL 72222) is a selective 5-HT3 receptor antagonist with an IC50 of 0.33 nM[1]. Neuroprotective effect[2].

IC50 & Target[1]

5-HT3 Receptor

0.33 nM (IC50)

体外研究
(In Vitro)

Blockade of 5-HT3 receptor with Bemesetron (MDL7222) reduces hydrogen peroxide-induced neurotoxicity in cultured rat cortical cells. Bemesetron (0.01, 0.1 and 1 μM, 15 hours) and Y25130 (0.05, 0.5 and 5 μM) concentration-dependently reduce the H2O2-induced decrease of MTT reduction showing 74.9±2.4 and 79.0 ±2.5% with 1 μM and 5 μM, respectively, which are maximal effects[2].
Pretreatment (20 minutes) with Bemesetron (1 μM), Y25130 (5 μM) or MK-801 (10 μM) significantly, but not completely, inhibits the H2O2-induced elevation of [Ca2+]c[2].
Bemesetron (1 μM, 15 hours) significantly blocks the H2O2-induced increase of caspase-3 immunoreactivity[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Bemesetron 相关抗体:

Cell Viability Assay[2]

Cell Line: Primary cortical neuronal cells
Concentration: 0.01-1 μM
Incubation Time: 20 minutes (pretreatment); 15 hours (post-incubation)
Result: Concentration-dependently reduced the H2O2-induced decrease of MTT reduction showing 74.9±2.4% with 1 μM, which was maximal effect.

Western Blot Analysis[2]

Cell Line: Primary cortical neuronal cells
Concentration: 1 μM
Incubation Time: 15 hours
Result: Blocked significantly the H2O2-induced increase of caspase-3 immunoreactivity.
体内研究
(In Vivo)

Bemesetron (0.1, 1 and 10 mg/kg; i.p.) is used in male adult albino mice. The lowest dose do not cause any significant change in catalepsy. However, Bemesetron (1 mg/kg) causes a significant reduction of catalepsy (from 90 min after Haloperidol), while 10 mg/kg significantly potentiates the phenomenon (from 60 min after Haloperidol). The maximum inhibition of catalepsy (about 75%) occurs at 120 min, and the maximum potentiation (about 4.5-times the control value) occurs at 60 min after Haloperidol[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male adult albino mice, weighing 26-36 g[3]
Dosage: 0.1-10 mg/kg
Administration: Intraperitoneally injected, 20 min (pretreatment) +180 min (treatment)
Result: Reduced catalepsy significantly at a dose of 1 mg/kg, whilst 10 mg/kg potentiated the phenomenon and 0.1 mg/kg was found to be without effect.
分子量

314.21

Formula

C15H17Cl2NO2
CAS 号
性状

固体

颜色

White to off-white

中文名称

贝美司琼
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 2 mg/mL (6.37 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.1826 mL 15.9129 mL 31.8258 mL
5 mM 0.6365 mL 3.1826 mL 6.3652 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: ≥99.0%

COA (194 KB)

产品使用指南 (1538 KB)
参考文献

Bemesetron 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1826 mL 15.9129 mL 31.8258 mL 79.5646 mL
5 mM 0.6365 mL 3.1826 mL 6.3652 mL 15.9129 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bemesetron40796-97-2MDL 72222贝美司琼MDL72222MDL-722225-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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