2. Vitamin D Related/Nuclear Receptor
  3. Nuclear Hormone Receptor 4A/NR4A
  4. C-DIM12

C-DIM12  (Synonyms: DIM-C-pPhCl)

目录号: HY-19808 纯度: 98.32%
COA 产品使用指南

摩尔计算器

C-DIM12 是一种有效，具有口服活性的 Nurr1 拮抗剂。C-DIM12 抑制肿瘤生长和自噬，诱导细胞凋亡（apoptosis）。C-DIM12 具有抗炎和神经保护作用，可用于癌症和神经系统疾病的研究。

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C-DIM12 Chemical Structure

C-DIM12 Chemical Structure

CAS No. : 178946-89-9

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
Free Sample (0.1 - 0.2 mg)   Apply now  
10 mM * 1 mL in DMSO ￥495
In-stock
5 mg ￥450
In-stock
10 mg ￥720
In-stock
25 mg ￥1530
In-stock
50 mg ￥2430
In-stock
100 mg ￥3870
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

C-DIM12 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

C-DIM12 is a potent, orally active Nurr1 antagonist. C-DIM12 inhibits the tumor growth and autophagy, and induces the cell apoptosis. C-DIM12 has anti-inflammatory and neuroprotective effects, and can be used for cancer and neurological disease study[1][2][3].

IC50 & Target

Nurr1/NR4A2

 

体外研究
(In Vitro)

C-DIM12 (15 μM, 3-5 天) 通过抑制细胞自噬降低 MiaPaCa2 细胞的增殖和存活[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

C-DIM12 相关抗体:
体内研究
(In Vivo)

C-DIM12 (每次 25 mg/kg, 14 天) 改善帕金森小鼠的神经胶质反应性[2]。
C-DIM12 (50-100 mg/kg, 每次 3 次)可减轻小鼠脑出血后脑炎症，促进功能恢复[3]。
C-DIM12 (30 mg/kg, 腹腔注射, 30 天) 抑制 NURR1-KO 细胞原位异种移植裸鼠的肿瘤生长和自噬现象，促进细胞凋亡[1]。
在C57BL/6雄性小鼠中的药代动力学分析[1]

Route Organ Dose (mg/kg) Area under Curve (ng/mL*min) t1/2 (min) Cmax (ng/mL)
i.g. Plasma 25 539,220 249 1120
i.g. Brain 25 2,273,711 265 3622

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MPTP-induced C57BL/6 male Parkinsonism mice [2]
Dosage: 25 mg/kg/day, 14day
Administration: Intragastric gavage (i.g.)
Result: Protected against the loss of DA neurons in the substantia nigra pars compacta and DA terminals in the striatum, maintained a ramified phenotype in microglia, and suppressed activation of astrocytes.
Animal Model: The ICR mice model of intracerebral hemorrhage induced by collagenase type VII[3]
Dosage: 50 and 100mg/kg/day at a 24-h interval, three times
Administration: Orally administration
Result: Improved the recovery of neurological function and prevented neuron loss in the hematoma, while suppressed activation of microglia/macrophages and expression of inflammatory mediators interleukin-6 and CC chemokine ligand 2.
Preserved axonal structures in the internal capsule and axonal transport function.
Decreased of iNOS mRNA expression.
Animal Model: MiaPaCa2 cells (Ctrl and NURR1-KO) orthotopic xenograft tumor models[1]
Dosage: 30 mg/kg, 30 day
Administration: Intraperitoneal injection (i.p.)
Result: Inhibited tumor growth and ATG7 and ATG12 mRNA levels, and induced apoptosis.
分子量

356.85

Formula

C23H17ClN2
CAS 号
性状

固体

颜色

Light yellow to brown

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : ≥ 100 mg/mL (280.23 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.8023 mL 14.0115 mL 28.0230 mL
5 mM 0.5605 mL 2.8023 mL 5.6046 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

C-DIM12 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8023 mL 14.0115 mL 28.0230 mL 70.0574 mL
5 mM 0.5605 mL 2.8023 mL 5.6046 mL 14.0115 mL
10 mM 0.2802 mL 1.4011 mL 2.8023 mL 7.0057 mL
15 mM 0.1868 mL 0.9341 mL 1.8682 mL 4.6705 mL
20 mM 0.1401 mL 0.7006 mL 1.4011 mL 3.5029 mL
25 mM 0.1121 mL 0.5605 mL 1.1209 mL 2.8023 mL
30 mM 0.0934 mL 0.4670 mL 0.9341 mL 2.3352 mL
40 mM 0.0701 mL 0.3503 mL 0.7006 mL 1.7514 mL
50 mM 0.0560 mL 0.2802 mL 0.5605 mL 1.4011 mL
60 mM 0.0467 mL 0.2335 mL 0.4670 mL 1.1676 mL
80 mM 0.0350 mL 0.1751 mL 0.3503 mL 0.8757 mL
100 mM 0.0280 mL 0.1401 mL 0.2802 mL 0.7006 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

C-DIM12178946-89-9DIM-C-pPhClNuclear Hormone Receptor 4A/NR4ANerve Growth Factor IB-like ReceptorPancreatic ductal adenocarcinomaMiaPaCa2Parkinsonismintracerebral hemorrhageinflammationapoptosisautophagyInhibitorinhibitorinhibit

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目录号：
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