1. Metabolic Enzyme/Protease
    Apoptosis
  2. HIF/HIF Prolyl-Hydroxylase
    Apoptosis
  3. EL-102

EL-102 

目录号: HY-16187 纯度: 99.76%
产品使用指南

EL102是HIF1α 的抑制剂,能够抑制微管蛋白聚合和减少它的稳定性。

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EL-102 Chemical Structure

EL-102 Chemical Structure

CAS No. : 1233948-61-2

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ¥2368 In-stock
1 mg ¥1100 In-stock
5 mg ¥2800 In-stock
10 mg ¥4500 In-stock
50 mg ¥9500 In-stock
100 mg ¥15000 In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

EL102 is a inhibitor of HIF1α , Which can inhibit tubulin polymerisation and decreased microtubule stability. target: HIF1α IC 50:20-40 nM.[1] in vitro : EL102 is a cytotoxic agent and also displays cytostatic properties, through flow cytometric analysis of PI-stained cells cultured for 24, 48 and 72 h, following treatment. EL102 induces apoptosis and causes G2/M arrest, preventing the cell from entering into mitosis. In vivo: CWR22 tumours were taken from an in vivo passage, cut into small fragments and transplanted subcutaneously (s.c.) into the flank of 48 nude mice. At day 13, when the tumours were palpable, mice were randomised into 10 groups with 8 mice each and treatment initiated. EL102 12 mg kg 1 via p.o. (0700 hours and 1700 hours daily).[1]

分子量

384.47

Formula

C₁₉H₁₆N₂O₃S₂

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : ≥ 36 mg/mL (93.64 mM)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.6010 mL 13.0049 mL 26.0098 mL
5 mM 0.5202 mL 2.6010 mL 5.2020 mL
10 mM 0.2601 mL 1.3005 mL 2.6010 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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产品名称:
EL-102
目录号:
HY-16187
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