2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. L-Hisidine (monohydrocholoride)

L-Hisidine (monohydrocholoride)  (Synonyms: L-组氨酸盐酸盐)

目录号: HY-N0833 纯度: 98.0%
COA 产品使用指南 技术支持

L-Hisidine是婴儿必需的氨基酸。L-Hisidine是线粒体谷氨酰胺转运的抑制剂。

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L-Hisidine (monohydrocholoride)

L-Hisidine (monohydrocholoride) Chemical Structure

CAS No. : 645-35-2

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Customer Review

Other Forms of L-Hisidine (monohydrocholoride):

L-Hisidine (monohydrocholoride) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

L-Hisidine is an essential amino acid for infants. L-Hisidine is an inhibitor of mitochondrial glutamine transport.

IC50 & Target

Microbial Metabolite

 

Human Endogenous Metabolite

 

体外研究
(In Vitro)

L-histidine completely inhibits growth and its effect on viability is inversely related to FLO11 expression. L-histidine does not affect the viability of the Δflo11 and S288c strains. L-histidine dramatically decreases air-liquid biofilm formation and adhesion to polystyrene of the flor yeasts with no effect on the transcription level of the FLO11 gene. Moreover, L-histidine modifies the chitin and glycans content on the cell-wall of flor yeasts[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

L-Hisidine (monohydrocholoride) 相关抗体:
体内研究
(In Vivo)

L-histidine (100 mg/kg) completely inhibits the brain edema in thioacetamide-treated rats[2]. Histamine release stimulated by high K+ from the hypothalamus in the L-histidine diet group is 60% of that in the control group. However, the concentrations of other monoamines and their metabolites are not changed by the L-histidine diet. The open-field tests show that the L-histidine diet group spends a shorter amount of time in the central zone, and the light/dark box tests demonstrate that the L-histidine diet group spends a shorter amount of time in the light box, suggesting that the L-histidine diet induced anxiety-like behaviors[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
分子量

191.62

Formula

C6H10ClN3O2
CAS 号
性状

固体

颜色

White to off-white

中文名称

L-组氨酸盐酸盐
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验： 

H2O 中的溶解度 : 50 mg/mL (260.93 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 5.2187 mL 26.0933 mL 52.1866 mL
5 mM 1.0437 mL 5.2187 mL 10.4373 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用，-20°C储存时，请在1年内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳，请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料

纯度: 98.0%

COA (288 KB) HNMR (130 KB)

产品使用指南 (1538 KB)
参考文献
Animal Administration
[2][3]

Rats: TAA (300 mg/kg i.p) is given to animals daily for 3 days. L-histidine (100 mg/kg) is dissolved in saline and injected (i.p.) daily 2 hours before each TAA injection. To prevent hypoglycemia and dehydration, rats are given 12.5 ml/kg of fluid therapy (5% dextrose and 0.45% saline with 20 mEq/L of potassium chloride) every 12 hours, s.c. Normal controls receive saline (vehicle used for TAA), whereas another group of rats are given L-histidine alone (100 mg/kg) daily for 3 days. TAA-treated rats are clinically monitored, and stages of encephalopathy are graded[2]. Mice: The control group is fed with the AIN-93G purified diet that contains 5.08 g L-histidine/kg, whereas the L-histidine diet group is fed with AIN-93G that contains 1.28 g L-histidine/kg (25% of the histidine content in AIN-93G). To equalize the total amount of amino acids, glutamine is added to the L-histidine diet to counterbalance the changes in the histidine content (18.32 g L-glutamine/kg AIN-93G vs. 23.72 g L-glutamine/kg L-histidine diet). Both diets are isonitrogenous. At 8 wk of age, the mice are weighed and assigned to 2 different diets. The mice are allowed ad libitum access to water and their respective diets, and they are housed for at least 2 wk in the laboratory before starting the experiments[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献

L-Hisidine (monohydrocholoride) 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用，-20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 5.2187 mL 26.0933 mL 52.1866 mL 130.4666 mL
5 mM 1.0437 mL 5.2187 mL 10.4373 mL 26.0933 mL
10 mM 0.5219 mL 2.6093 mL 5.2187 mL 13.0467 mL
15 mM 0.3479 mL 1.7396 mL 3.4791 mL 8.6978 mL
20 mM 0.2609 mL 1.3047 mL 2.6093 mL 6.5233 mL
25 mM 0.2087 mL 1.0437 mL 2.0875 mL 5.2187 mL
30 mM 0.1740 mL 0.8698 mL 1.7396 mL 4.3489 mL
40 mM 0.1305 mL 0.6523 mL 1.3047 mL 3.2617 mL
50 mM 0.1044 mL 0.5219 mL 1.0437 mL 2.6093 mL
60 mM 0.0870 mL 0.4349 mL 0.8698 mL 2.1744 mL
80 mM 0.0652 mL 0.3262 mL 0.6523 mL 1.6308 mL
100 mM 0.0522 mL 0.2609 mL 0.5219 mL 1.3047 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

L-Hisidine (monohydrocholoride)645-35-2L-组氨酸盐酸盐Endogenous MetaboliteInhibitorinhibitorinhibit

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