1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. RG7800 hydrochloride

RG7800 hydrochloride (Synonyms: RO6885247 hydrochloride)

目录号: HY-101792A 纯度: 99.59%
产品使用指南

RG7800 hydrochloride 是一种可口服的 SMN2 剪接调节剂,对 SMN2 剪接及 SMN 蛋白的 EC1.5x 值分别为 23 nM 和 87 nM。

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RG7800 hydrochloride Chemical Structure

RG7800 hydrochloride Chemical Structure

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规格 价格 是否有货 数量
5 mg ¥1200
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10 mg ¥1900
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50 mg ¥6600
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100 mg ¥9900
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Other Forms of RG7800 hydrochloride:

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Top Publications Citing Use of Products
  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

RG7800 hydrochloride is an orally active SMN2 splicing modulator, with EC1.5xs of 23 nM and 87 nM for SMN2 splicing and SMN protein; RG7800 hydrochloride has the potential to treat spinal muscular atrophy.

IC50 & Target

EC1.5x: 23 nM (SMN2 splicing), 87 nM (SMN protein)[1]

体外研究
(In Vitro)

RG7800 hydrochloride is an orally active SMN2 splicing modulator, with EC1.5xs of 23 nM and 87 nM for SMN2 splicing and SMN protein; and is the first small molecule SMN2 splicing modifier to enter human clinical trials[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

RG7800 is a favorable agent metabolism and pharmacokinetic (DMPK) profile in the rat and in cynomolgus monkey with good oral bioavailability. RG7800 (1, 3, 10 mg/kg, p.o.) dose-dependently elevates the SMN protein level in the brain and in peripheral tissue of Δ7 mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Formula

C24H28N6O.xHCl

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro: 

H2O : ≥ 113.5 mg/mL

* "≥" means soluble, but saturation unknown.

参考文献
Animal Administration
[1]

Mice[1]
Homozygous Δ7 mice are dosed ip with RG7800 or vehicle (100% DMSO, 2.5 mL/kg) once per day from PND3 through postnatal day 3 (PND23), and the dosing regimen is switched on PND24 to a 3-fold higher oral dose once daily in 0.5% HPMC and 0.1% Tween 80. Litters are randomized across groups. Body weight and survival are assessed daily. Survival analysis is done using GraphPad Prism (log-rank test), and a p <0.05 is considered as significant[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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产品名称:
RG7800 hydrochloride
目录号:
HY-101792A
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