1. Cell Cycle/DNA Damage
  2. DNA/RNA Synthesis
  3. RG7800 tetrahydrochloride

RG7800 tetrahydrochloride  (Synonyms: RO6885247 tetrahydrochloride)

目录号: HY-101792A 纯度: 99.61%
COA 产品使用指南

RG7800 hydrochloride 是一种可口服的 SMN2 剪接调节剂,对 SMN2 剪接及 SMN 蛋白的 EC1.5x 值分别为 23 nM 和 87 nM。

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RG7800 tetrahydrochloride Chemical Structure

RG7800 tetrahydrochloride Chemical Structure

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
5 mg ¥1000
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10 mg ¥1600
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50 mg ¥4800
In-stock
100 mg ¥6800
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500 mg   询价  

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Customer Review

Other Forms of RG7800 tetrahydrochloride:

  • 生物活性

  • 实验参考方法

  • 纯度 & 产品资料

  • 参考文献

生物活性

RG7800 hydrochloride is an orally active SMN2 splicing modulator, with EC1.5xs of 23 nM and 87 nM for SMN2 splicing and SMN protein; RG7800 hydrochloride has the potential to treat spinal muscular atrophy.

IC50 & Target

EC1.5x: 23 nM (SMN2 splicing), 87 nM (SMN protein)[1]

体外研究
(In Vitro)

RG7800 hydrochloride is an orally active SMN2 splicing modulator, with EC1.5xs of 23 nM and 87 nM for SMN2 splicing and SMN protein; and is the first small molecule SMN2 splicing modifier to enter human clinical trials[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

RG7800 is a favorable agent metabolism and pharmacokinetic (DMPK) profile in the rat and in cynomolgus monkey with good oral bioavailability. RG7800 (1, 3, 10 mg/kg, p.o.) dose-dependently elevates the SMN protein level in the brain and in peripheral tissue of Δ7 mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
分子量

562.36

Formula

C24H32Cl4N6O

性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验: 

H2O 中的溶解度 : ≥ 113.5 mg/mL (201.83 mM)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7782 mL 8.8911 mL 17.7822 mL
5 mM 0.3556 mL 1.7782 mL 3.5564 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
该产品水溶性佳,请具体参考实测 水 / PBS / Saline 中的溶解度数据。
您所需的储备液浓度超过该产品的实测溶解度,如有需要,请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献
Animal Administration
[1]

Mice[1]
Homozygous Δ7 mice are dosed ip with RG7800 or vehicle (100% DMSO, 2.5 mL/kg) once per day from PND3 through postnatal day 3 (PND23), and the dosing regimen is switched on PND24 to a 3-fold higher oral dose once daily in 0.5% HPMC and 0.1% Tween 80. Litters are randomized across groups. Body weight and survival are assessed daily. Survival analysis is done using GraphPad Prism (log-rank test), and a p <0.05 is considered as significant[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

RG7800 tetrahydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.7782 mL 8.8911 mL 17.7822 mL 44.4555 mL
5 mM 0.3556 mL 1.7782 mL 3.5564 mL 8.8911 mL
10 mM 0.1778 mL 0.8891 mL 1.7782 mL 4.4456 mL
15 mM 0.1185 mL 0.5927 mL 1.1855 mL 2.9637 mL
20 mM 0.0889 mL 0.4446 mL 0.8891 mL 2.2228 mL
25 mM 0.0711 mL 0.3556 mL 0.7113 mL 1.7782 mL
30 mM 0.0593 mL 0.2964 mL 0.5927 mL 1.4819 mL
40 mM 0.0445 mL 0.2223 mL 0.4446 mL 1.1114 mL
50 mM 0.0356 mL 0.1778 mL 0.3556 mL 0.8891 mL
60 mM 0.0296 mL 0.1482 mL 0.2964 mL 0.7409 mL
80 mM 0.0222 mL 0.1111 mL 0.2223 mL 0.5557 mL
100 mM 0.0178 mL 0.0889 mL 0.1778 mL 0.4446 mL

* 备注:如您选择水作为储备液,请稀释至工作液后,再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
RG7800 tetrahydrochloride
目录号:
HY-101792A
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