2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. TRP Channel
  4. SAR7334

SAR7334 是一种有效的 TRPC6 特异性抑制剂，能够抑制 TRPC6 电流，IC50 值为 7.9 nM。

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SAR7334

SAR7334 Chemical Structure

CAS No. : 1333210-07-3

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥1295
In-stock
1 mg ￥909
In-stock
5 mg ￥1600
In-stock
10 mg ￥2560
In-stock
50 mg ￥4750
In-stock
100 mg ￥5940
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of SAR7334:

SAR7334 相关抗体

Top Publications Citing Use of Products

查看 TRP Channel 亚型特异性产品:

查看所有亚型
TRPC TRPM TRPV TRPA TRPML

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SAR7334 is a potent and specific TRPC6 inhibitor, inhibiting TRPC6 currents with IC50 of 7.9 nM.

IC50 & Target

IC50: 7.9 nM (TRPC6 currents)[3]
细胞效力
(Cellular Effect)
Cell Line Type Value Description References
CHO IC50
282 nM
Compound: 52; SAR7334
Inhibition of human TRPC3 expressed in CHO cells assessed as reduction in OAG-induced calcium influx after 10 mins by fluo-4/AM dye based FLIPR assay
Inhibition of human TRPC3 expressed in CHO cells assessed as reduction in OAG-induced calcium influx after 10 mins by fluo-4/AM dye based FLIPR assay
[PMID: 30943030]
HEK293 IC50
226 nM
Compound: 52; SAR7334
Inhibition of human TRPC7 expressed in HEK293 cells assessed as reduction in OAG-induced calcium influx after 10 mins by fluo-4/AM dye based FLIPR assay
Inhibition of human TRPC7 expressed in HEK293 cells assessed as reduction in OAG-induced calcium influx after 10 mins by fluo-4/AM dye based FLIPR assay
[PMID: 30943030]
HEK293 IC50
7.9 nM
Compound: 52; SAR7334
Inhibition of human TRPC6 expressed in HEK293 cells assessed as reduction in TRPC6-induced current by Whole-cell patch-clamp
Inhibition of human TRPC6 expressed in HEK293 cells assessed as reduction in TRPC6-induced current by Whole-cell patch-clamp
[PMID: 30943030]
HEK293 IC50
9.5 nM
Compound: 52; SAR7334
Inhibition of human TRPC6 expressed in HEK293 cells assessed as reduction in OAG-induced calcium influx after 10 mins by fluo-4/AM dye based FLIPR assay
Inhibition of human TRPC6 expressed in HEK293 cells assessed as reduction in OAG-induced calcium influx after 10 mins by fluo-4/AM dye based FLIPR assay
[PMID: 30943030]
体外研究
(In Vitro)

SAR7334 抑制 TRPC6、TRPC3 和 TRPC7 介导的 Ca2+ 流入细胞，IC50 分别为 9.5、282 和 226 nM[1][2][3]，而 TRPC4 和 TRPC5 介导的 Ca2+ 进入不受影响。SAR7334 (1 μM) 可显著阻断足细胞中 Ang II 引起的钙内流[1]。SAR7334 (1 μM) 对 SOCE[2] 的影响微乎其微。SAR7334 剂量依赖性地降低 TRPC6 电流，IC50 为 7.9 nM。 SAR7334 (100 nM) 显著降低 TRPC6 电流[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SAR7334 相关抗体:
体内研究
(In Vivo)

SAR7334（10 mg/kg，口服）可抑制小鼠离体灌注肺中 TRPC6 依赖性急性 HPV。SAR7334 表明其适合长期口服给药。在一项初步短期研究中，SAR7334 不会改变自发性高血压大鼠 (SHR) 的平均动脉压[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

367.87

Formula

C21H22ClN3O
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
溶解性数据
细胞实验： 

DMSO 中的溶解度 : ≥ 370 mg/mL (1005.79 mM; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

* "≥" means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.7184 mL 13.5918 mL 27.1835 mL
5 mM 0.5437 mL 2.7184 mL 5.4367 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.82%

COA (293 KB) LCMS (96 KB)

产品使用指南 (1538 KB)
参考文献

SAR7334 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7184 mL 13.5918 mL 27.1835 mL 67.9588 mL
5 mM 0.5437 mL 2.7184 mL 5.4367 mL 13.5918 mL
10 mM 0.2718 mL 1.3592 mL 2.7184 mL 6.7959 mL
15 mM 0.1812 mL 0.9061 mL 1.8122 mL 4.5306 mL
20 mM 0.1359 mL 0.6796 mL 1.3592 mL 3.3979 mL
25 mM 0.1087 mL 0.5437 mL 1.0873 mL 2.7184 mL
30 mM 0.0906 mL 0.4531 mL 0.9061 mL 2.2653 mL
40 mM 0.0680 mL 0.3398 mL 0.6796 mL 1.6990 mL
50 mM 0.0544 mL 0.2718 mL 0.5437 mL 1.3592 mL
60 mM 0.0453 mL 0.2265 mL 0.4531 mL 1.1326 mL
80 mM 0.0340 mL 0.1699 mL 0.3398 mL 0.8495 mL
100 mM 0.0272 mL 0.1359 mL 0.2718 mL 0.6796 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SAR73341333210-07-3SAR 7334SAR-7334TRP ChannelTransient receptor potential channelsInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-15699
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