1. Signaling Pathways
  2. Cell Cycle/DNA Damage
  3. p97


p97, an abundant hexameric ATPase of the AAA family, is involved in homotypic membrane fusion. It is thought to disassemble SNARE complexes formed during the process of membrane fusion. Two structures have been reported: a crystal structure of the N-terminal and D1 ATPase domains of murine p97 at 2.9 A resolution, and a cryoelectron microscopy structure of full-length rat p97 at 18 A resolution. Together, these structures show that the D1 and D2 hexamers pack in a tail-to-tail arrangement, and that the N domain is flexible. A comparison with NSF D2 (ATP complex) reveals possible conformational changes induced by ATP hydrolysis.

p97 相关产品 (5):

目录号 产品名 作用方式 纯度
  • HY-15713
    NMS-873 Inhibitor 99.86%
    NMS-873 是一种有效,选择性的 VCP/p97 变构抑制剂,IC50 值为 30 nM。
  • HY-15945
    DBeQ Inhibitor 99.94%
    DBeQ 是一种有效的,选择性的,ATP 竞争性的 p97 抑制剂,对 p97(wt) 和 p97(C522A) 的 IC50 值分别为 1.5 μM 和 1.6 μM,同时可抑制 Vps4IC50 值为 11.5 μM。
  • HY-123872
    MSC1094308 Inhibitor 99.75%
    MSC1094308 是一种可逆的、II 型 AAA ATPase (VCP)/p97 和I型 AAA ATPase VPS4B 的变构抑制剂,对VPS4B 和 p97 的IC50 值分别为 0.71 μM 和 7.2 μM。
  • HY-19797A
    ML241 hydrochloride Inhibitor 99.86%
    ML241 hydrochloride 是一种有效的 p97 抑制剂,IC50 值为 100 nM。
  • HY-15714
    NMS-859 Inhibitor
    NMS-859 是一种有效的,共价的 VCP (p97) 抑制剂,细胞中分别在 60 μM 和 1 mM ATP 的条件下,对野生型 VCP 的 IC50 值分别为 0.37 和 0.36 μM。
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