2. Anti-infection Apoptosis Cell Cycle/DNA Damage
  3. HIV Apoptosis Reverse Transcriptase Telomerase
  4. Abacavir hydrochloride

Abacavir hydrochloride 是一种具有口服活性、竞争性核苷酸逆转录酶 (nucleoside reverse transcriptase) 抑制剂。 Abacavir hydrochloride 可抑制 HIV 的复制。Abacavir hydrochloride 在前列腺癌细胞系中显示出抗癌活性。Abacavir hydrochloride 可透过血脑屏障，抑制端粒酶 (telomerase) 活性。

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Abacavir hydrochloride Chemical Structure

Abacavir hydrochloride Chemical Structure

CAS No. : 136777-48-5

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Abacavir hydrochloride 的其他形式现货产品:

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Abacavir hydrochloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Abacavir hydrochloride is a competitive, orally active nucleoside reverse transcriptase inhibitor. Abacavir hydrochloride can inhibits the replication of HIV. Abacavir hydrochloride shows anticancer activity in prostate cancer cell lines. Abacavir hydrochloride can trespass the blood-brain-barrier and suppresses telomerase activity[1][2][3].

体外研究
(In Vitro)

Abacavir hydrochloride (15 and 150 μM, 0-120 h) inhibits cell growth, affects cell cycle progression, induces senescence and modulates LINE-1 mRNA expression in prostate cancer cell lines[1].
Abacavir hydrochloride (15 and 150 μM, 18 h) significantly reduces cell migration and inhibits cell invasion[1].
Abacavir hydrochloride induces fat apoptosis[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Abacavir hydrochloride 相关抗体:

Cell Proliferation Assay[1]

Cell Line: PC3, LNCaP and WI-38
Concentration: 15 μM and 150 μM
Incubation Time: 0, 24, 48, 72 and 96 hours
Result: Showed a dose-dependent growth inhibition on PC3 and LNCaP.

Cell Cycle Analysis[1]

Cell Line: PC3, LNCaP and WI-38
Concentration: 150 μM
Incubation Time: 0, 18, 24, 48, 72, 96 and 120 hours
Result: Caused a very high accumulation of cells in S phase in PC3 and LNCaP cells, and G2/M phase increment was observed in PC3 cells.

Cell Migration Assay [1]

Cell Line: PC3, LNCaP and WI-38
Concentration: 15 and 150 μM
Incubation Time: 18 hours
Result: Significantly reduced cell migration.

Cell Invasion Assay[1]

Cell Line: PC3, LNCaP and WI-38
Concentration: 15 and 150 μM
Incubation Time: 18 hours
Result: Significantly inhibited cell invision.
体内研究
(In Vivo)

Abacavir hydrochloride (100 and 200 mg/kg, p.o.; 4 h) dose-dependently promotes thrombus formation[2].
Abacavir hydrochloride (50 mg/kg/d; i.p.; 14 d) with 0.1 mg/kg/d Decitabine (HY-A0004) enhances survival of high-risk medulloblastoma-bearing mice[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male mice (9-weeks old, 22-30 g) - wild-type (WT) C57BL/6 or homozygous knockout (P2rx7 KO, B6.129P2-P2rx7tm1Gab/J)[2]
Dosage: Route 1: 2.5, 5, and 7.5 μg/mL, 100 μL
Route 2: 100 and 200 mg/kg
Administration: Intrascrotal or oral administration for 4 h
Result: Dose-dependently promoted thrombus formation.
Animal Model: NSGTM mice, patient-derived xenograft (PDX) cells of non-WNT/non-SHH, Group 3 and of SHH/ TP53-mutated medulloblastoma[3]
Dosage: 50 mg/kg/d with 0.1 mg/kg/d Decitabine
Administration: Intraperitoneal injection, daily for 14 days
Result: Inhibited tumor growth and enhanced mouse survival.
Clinical Trial
分子量

322.79

Formula

C14H19ClN6O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Abacavir hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Abacavir136777-48-5HIVApoptosisReverse TranscriptaseTelomeraseHuman immunodeficiency virusprostate cancerPC3LNCaPanticancermedulloblastomaInhibitorinhibitorinhibit

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