2. Apoptosis Anti-infection
  3. HSV Apoptosis Antibiotic Bacterial
  4. Acyclovir sodium

Acyclovir sodium  (Synonyms: 阿昔洛韦钠盐; Aciclovir sodium; Acycloguanosine sodium)

目录号: HY-17422A 纯度: 99.82%
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Acyclovir (Aciclovir) sodium 是一种有效的口服抗病毒活性分子。Acyclovir sodium 具有抗疱疹活性，对 HSV-1 和 HSV-2 的 IC50 值分别为 0.85 μM 和 0.86 μM。Acyclovir sodium 诱导细胞周期扰动和凋亡 (apoptosis)。Acyclovir sodium 可预防急性白血病的诱导疗法中的细菌感染。

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Acyclovir sodium

Acyclovir sodium Chemical Structure

CAS No. : 69657-51-8

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规格 价格 是否有货 数量
25 mg ￥346
In-stock
50 mg ￥550
In-stock
100 mg ￥880
In-stock
500 mg ￥1500
In-stock
1 g   询价  
5 g   询价  

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Customer Review

Other Forms of Acyclovir sodium:

Acyclovir sodium 相关抗体

Top Publications Citing Use of Products

    Acyclovir sodium purchased from MCE. Usage Cited in: Biomed Pharmacother. 2023 Jun:162:114595.  [Abstract]

    Acyclovir (ACV; 2.5 μM; 48 h) significantly inhibits the expression of gD in HSV-2-infected HeLa, Vero, Beas-2B and HaCaT cells.

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    HSV-1 HSV-2 HSV

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    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Acyclovir (Aciclovir) sodium is a potent, orally active antiviral agent. Acyclovir sodium has antiherpetic activity with IC50 values of 0.85 μM and 0.86 μM for HSV-1 and HSV-2, respectively. Acyclovir sodium induces cell cycle perturbation and apoptosis. Acyclovir sodium prevents bacterial infections during induction therapy for acute leukaemia[1][2][3][4].

    IC50 & Target[2]

    HSV-1

    0.85 μM (IC50)

    HSV-2

    0.86 μM (IC50)

    体外研究
    (In Vitro)

    Acyclovir (Aciclovir) sodium (3-100 µM; 24-72 hours; Jurkat, U937, and K562 leukemia cells) reduces cell viability in a dose- and time-dependent[1].
    Acyclovir (Aciclovir) sodium (10-100 µM; 24-72 hours; Jurkat cells) blocks DNA synthesis, thereby arresting the cell cycle in G2/M and S phases and increasing the sub-G1 hypodiploid peak in a dose-dependent manner[1].
    Acyclovir (Aciclovir) sodium (10-100 µM; 24-72 hours; Jurkat cells) induces apoptosis through activates caspase-3 and presences nuclear DNA fragmentation[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Acyclovir sodium 相关抗体:

    Cell Viability Assay[1]

    Cell Line: Jurkat, U937 and K562 leukemia cells
    Concentration: 3, 10, 30 and 100 µM
    Incubation Time: 24, 48 and 72 hours
    Result: Showed a dose- and time-dependent reduction of cell viability.

    Apoptosis Analysis[1]

    Cell Line: Jurkat cells
    Concentration: 10 and 100 µM
    Incubation Time: 24, 48 and 72 hours
    Result: Increased of caspase-3 activity and cleavaged the internucleosomal DNA.

    Cell Cycle Analysis[1]

    Cell Line: Jurkat cells
    Concentration: 10 and 100 µM
    Incubation Time: 24, 48 and 72 hours
    Result: Revealed a dose-dependent accumulation of cells in S phase after 24 and 48 h. Showed a dose-dependent increase of the sub-G1 hypodiploid peak after 72 h.
    体内研究
    (In Vivo)

    Acyclovir (Aciclovir) sodium (20 mg/kg; p.o.; three times daily; for 10 d; BALB/c mice) suppresses the development of skin lesions and results in a dissociation between DTH response and antibody production[3]

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Specific-pathogen-free BALB/c mice (7-week-old) infected with HSV-1[3]
    Dosage: 20 mg/kg
    Administration: Oral administration; three times daily; for 10 days
    Result: Suppressed the development of skin lesions and resulted in a dissociation between DTH response and antibody production.
    Clinical Trial
    分子量

    248.19

    Formula

    C8H11N5NaO3
    CAS 号
    性状

    固体

    颜色

    White to off-white

    中文名称

    阿昔洛韦钠盐；阿昔洛维钠盐；开糖环鸟苷钠盐；羟乙氧甲鸟嘌呤钠盐；无环鸟嘌呤核苷钠盐；无环鸟嘌呤钠盐；无环鸟苷钠盐
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    溶解性数据
    细胞实验： 

    H2O 中的溶解度 : 6.25 mg/mL (25.18 mM; 超声助溶)

    配制储备液
    浓度 溶剂体积 质量 1 mg 5 mg 10 mg
    1 mM 4.0292 mL 20.1459 mL 40.2917 mL
    5 mM 0.8058 mL 4.0292 mL 8.0583 mL
    查看完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    • 摩尔计算器

    • 稀释计算器

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量
    =
    浓度
    ×
    体积
    ×
    分子量 *

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start)

    C1

    ×
    体积 (start)

    V1

    =
    浓度 (final)

    C2

    ×
    体积 (final)

    V2

    动物溶解方案计算器
    请输入动物实验的基本信息：

    给药剂量

    mg/kg

    动物的平均体重

    g

    每只动物的给药体积

    μL

    动物数量

    只
    由于实验过程有损耗，建议您多配一只动物的量
    计算结果
    工作液所需浓度 : mg/mL
    您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
    纯度 & 产品资料
    参考文献

    Acyclovir sodium 相关分类

    完整储备液配制表

    * 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
    储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

    可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 4.0292 mL 20.1459 mL 40.2917 mL 100.7293 mL
    5 mM 0.8058 mL 4.0292 mL 8.0583 mL 20.1459 mL
    10 mM 0.4029 mL 2.0146 mL 4.0292 mL 10.0729 mL
    15 mM 0.2686 mL 1.3431 mL 2.6861 mL 6.7153 mL
    20 mM 0.2015 mL 1.0073 mL 2.0146 mL 5.0365 mL
    25 mM 0.1612 mL 0.8058 mL 1.6117 mL 4.0292 mL

    * 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Acyclovir69657-51-8AciclovirAcycloguanosine阿昔洛韦钠盐阿昔洛维钠盐开糖环鸟苷钠盐羟乙氧甲鸟嘌呤钠盐无环鸟嘌呤核苷钠盐无环鸟嘌呤钠盐无环鸟苷钠盐HSVApoptosisAntibioticBacterialHerpes simplex virusimmunosuppressionantibodythymidinekinaseDNApolymerasetriphosphateanti-herpeticInhibitorinhibitorinhibit

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