2. Apoptosis Anti-infection
  3. HSV Apoptosis Antibiotic Bacterial
  4. Acyclovir sodium

Acyclovir sodium  (Synonyms: 阿昔洛韦钠盐; Aciclovir sodium; Acycloguanosine sodium)

目录号: HY-17422A
产品使用指南

摩尔计算器

Acyclovir (Aciclovir) sodium 是一种有效的口服抗病毒活性分子。Acyclovir sodium 具有抗疱疹活性，对 HSV-1 和 HSV-2 的 IC50 值分别为 0.85 μM 和 0.86 μM。Acyclovir sodium 诱导细胞周期扰动和凋亡 (apoptosis)。Acyclovir sodium 可预防急性白血病的诱导疗法中的细菌感染。

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Acyclovir sodium Chemical Structure

Acyclovir sodium Chemical Structure

CAS No. : 69657-51-8

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Acyclovir sodium 的其他形式现货产品:

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Other Forms of Acyclovir sodium:

Acyclovir sodium 相关抗体

Top Publications Citing Use of Products

    Acyclovir sodium purchased from MCE. Usage Cited in: Biomed Pharmacother. 2023 Mar 27;162:114595.  [Abstract]

    Acyclovir (ACV; 2.5 μM; 48 h) significantly inhibits the expression of gD in HSV-2-infected HeLa, Vero, Beas-2B and HaCaT cells.

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    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Acyclovir (Aciclovir) sodium is a potent, orally active antiviral agent. Acyclovir sodium has antiherpetic activity with IC50 values of 0.85 μM and 0.86 μM for HSV-1 and HSV-2, respectively. Acyclovir sodium induces cell cycle perturbation and apoptosis. Acyclovir sodium prevents bacterial infections during induction therapy for acute leukaemia[1][2][3][4].

    IC50 & Target[2]

    HSV-1

    0.85 μM (IC50)

    HSV-2

    0.86 μM (IC50)

    体外研究
    (In Vitro)

    Acyclovir (Aciclovir) sodium (3-100 µM; 24-72 hours; Jurkat, U937, and K562 leukemia cells) reduces cell viability in a dose- and time-dependent[1].
    Acyclovir (Aciclovir) sodium (10-100 µM; 24-72 hours; Jurkat cells) blocks DNA synthesis, thereby arresting the cell cycle in G2/M and S phases and increasing the sub-G1 hypodiploid peak in a dose-dependent manner[1].
    Acyclovir (Aciclovir) sodium (10-100 µM; 24-72 hours; Jurkat cells) induces apoptosis through activates caspase-3 and presences nuclear DNA fragmentation[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Acyclovir sodium 相关抗体:

    Cell Viability Assay[1]

    Cell Line: Jurkat, U937 and K562 leukemia cells
    Concentration: 3, 10, 30 and 100 µM
    Incubation Time: 24, 48 and 72 hours
    Result: Showed a dose- and time-dependent reduction of cell viability.

    Apoptosis Analysis[1]

    Cell Line: Jurkat cells
    Concentration: 10 and 100 µM
    Incubation Time: 24, 48 and 72 hours
    Result: Increased of caspase-3 activity and cleavaged the internucleosomal DNA.

    Cell Cycle Analysis[1]

    Cell Line: Jurkat cells
    Concentration: 10 and 100 µM
    Incubation Time: 24, 48 and 72 hours
    Result: Revealed a dose-dependent accumulation of cells in S phase after 24 and 48 h. Showed a dose-dependent increase of the sub-G1 hypodiploid peak after 72 h.
    体内研究
    (In Vivo)

    Acyclovir (Aciclovir) sodium (20 mg/kg; p.o.; three times daily; for 10 d; BALB/c mice) suppresses the development of skin lesions and results in a dissociation between DTH response and antibody production[3]

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Specific-pathogen-free BALB/c mice (7-week-old) infected with HSV-1[3]
    Dosage: 20 mg/kg
    Administration: Oral administration; three times daily; for 10 days
    Result: Suppressed the development of skin lesions and resulted in a dissociation between DTH response and antibody production.
    Clinical Trial
    分子量

    248.19

    Formula

    C8H11N5NaO3
    CAS 号
    中文名称

    阿昔洛韦钠盐；阿昔洛维钠盐；开糖环鸟苷钠盐；羟乙氧甲鸟嘌呤钠盐；无环鸟嘌呤核苷钠盐；无环鸟嘌呤钠盐；无环鸟苷钠盐
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Acyclovir sodium 相关分类

    • 摩尔计算器

    • 稀释计算器

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    The dilution calculator equation

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    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Acyclovir69657-51-8AciclovirAcycloguanosine阿昔洛韦钠盐阿昔洛维钠盐开糖环鸟苷钠盐羟乙氧甲鸟嘌呤钠盐无环鸟嘌呤核苷钠盐无环鸟嘌呤钠盐无环鸟苷钠盐HSVApoptosisAntibioticBacterialHerpes simplex virusimmunosuppressionantibodythymidinekinaseDNApolymerasetriphosphateanti-herpeticInhibitorinhibitorinhibit

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