1. Apoptosis Anti-infection
  2. HSV Apoptosis Antibiotic Bacterial
  3. Acyclovir sodium

Acyclovir sodium  (Synonyms: 阿昔洛韦钠盐; Aciclovir sodium; Acycloguanosine sodium)

目录号: HY-17422A
产品使用指南

Acyclovir (Aciclovir) sodium 是一种有效的口服抗病毒活性分子。Acyclovir sodium 具有抗疱疹活性,对 HSV-1HSV-2IC50 值分别为 0.85 μM 和 0.86 μM。Acyclovir sodium 诱导细胞周期扰动和凋亡 (apoptosis)。Acyclovir sodium 可预防急性白血病的诱导疗法中的细菌感染。

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Acyclovir sodium Chemical Structure

Acyclovir sodium Chemical Structure

CAS No. : 69657-51-8

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Acyclovir sodium 的其他形式现货产品:

Customer Review

Other Forms of Acyclovir sodium:

    Acyclovir sodium purchased from MCE. Usage Cited in: Biomed Pharmacother. 2023 Mar 27;162:114595.  [Abstract]

    Acyclovir (ACV; 2.5 μM; 48 h) significantly inhibits the expression of gD in HSV-2-infected HeLa, Vero, Beas-2B and HaCaT cells.
    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Acyclovir (Aciclovir) sodium is a potent, orally active antiviral agent. Acyclovir sodium has antiherpetic activity with IC50 values of 0.85 μM and 0.86 μM for HSV-1 and HSV-2, respectively. Acyclovir sodium induces cell cycle perturbation and apoptosis. Acyclovir sodium prevents bacterial infections during induction therapy for acute leukaemia[1][2][3][4].

    IC50 & Target[2]

    HSV-1

    0.85 μM (IC50)

    HSV-2

    0.86 μM (IC50)

    体外研究
    (In Vitro)

    Acyclovir (Aciclovir) sodium (3-100 µM; 24-72 hours; Jurkat, U937, and K562 leukemia cells) reduces cell viability in a dose- and time-dependent[1].
    Acyclovir (Aciclovir) sodium (10-100 µM; 24-72 hours; Jurkat cells) blocks DNA synthesis, thereby arresting the cell cycle in G2/M and S phases and increasing the sub-G1 hypodiploid peak in a dose-dependent manner[1].
    Acyclovir (Aciclovir) sodium (10-100 µM; 24-72 hours; Jurkat cells) induces apoptosis through activates caspase-3 and presences nuclear DNA fragmentation[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Cell Viability Assay[1]

    Cell Line: Jurkat, U937 and K562 leukemia cells
    Concentration: 3, 10, 30 and 100 µM
    Incubation Time: 24, 48 and 72 hours
    Result: Showed a dose- and time-dependent reduction of cell viability.

    Apoptosis Analysis[1]

    Cell Line: Jurkat cells
    Concentration: 10 and 100 µM
    Incubation Time: 24, 48 and 72 hours
    Result: Increased of caspase-3 activity and cleavaged the internucleosomal DNA.

    Cell Cycle Analysis[1]

    Cell Line: Jurkat cells
    Concentration: 10 and 100 µM
    Incubation Time: 24, 48 and 72 hours
    Result: Revealed a dose-dependent accumulation of cells in S phase after 24 and 48 h. Showed a dose-dependent increase of the sub-G1 hypodiploid peak after 72 h.
    体内研究
    (In Vivo)

    Acyclovir (Aciclovir) sodium (20 mg/kg; p.o.; three times daily; for 10 d; BALB/c mice) suppresses the development of skin lesions and results in a dissociation between DTH response and antibody production[3]

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Specific-pathogen-free BALB/c mice (7-week-old) infected with HSV-1[3]
    Dosage: 20 mg/kg
    Administration: Oral administration; three times daily; for 10 days
    Result: Suppressed the development of skin lesions and resulted in a dissociation between DTH response and antibody production.
    Clinical Trial
    分子量

    248.19

    Formula

    C8H11N5NaO3

    CAS 号
    中文名称

    阿昔洛韦钠盐;阿昔洛维钠盐;开糖环鸟苷钠盐;羟乙氧甲鸟嘌呤钠盐;无环鸟嘌呤核苷钠盐;无环鸟嘌呤钠盐;无环鸟苷钠盐

    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.

    纯度 & 产品资料
    参考文献
    • 摩尔计算器

    • 稀释计算器

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    质量   浓度   体积   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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