1. GPCR/G Protein
    Metabolic Enzyme/Protease
  2. Angiotensin Receptor
    Angiotensin-converting Enzyme (ACE)
  3. Alamandine

Alamandine 

目录号: HY-P3108
产品使用指南

Alamandine 是一种血管活性肽,是肾素-血管紧张素系统 (RAS) 的成员,还是一种 G 蛋白偶联受体 MrgD 的内源性配体。Alamandine 可通过抗高血压作用来保护肾脏和心脏。

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Custom Peptide Synthesis

Alamandine Chemical Structure

Alamandine Chemical Structure

CAS No. : 1176306-10-7

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     可免费申领三个不同产品的试用装。

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Description

Alamandine, a member of the renin-angiotensin system (RAS), a vasoactive peptide, is an endogenous ligand of the G protein-coupled receptor MrgD. Alamandine targets to protect the kidney and heart through anti-hypertensive actions[1][2].

In Vitro

Alamandine is generated by catalysis of Ang A via ACE2 or directly from Angiotensin 1-7 (Ang-(1-7)). Derived from angiotensin II (Ang II) by Ang II-converting enzyme 2 (ACE2), it shows vasodilating (thus protective) properties. Ang (1-7) can be decarboxylated to a peptide called Alamandine. Alamandine is also an endogenous peptide identified in human blood[1].
Alamandine elevates cAMP concentration in primary endothelial and mesangial cells, also suggesting Gs coupling[2].
Alamandine decreases secretion, expression, and blood levels of leptin. Alamandine induced expression of iNOS and plasminogen activator inhibitor-1 (PAI-1) in adipose tissue and isolated adipocytes[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Alamandine (0.15  μL/h; administered by mini-osmotic pumps; for 6 weeks) treatment ameliorates hypertension and impaires left ventricle (LV) function in SHRs. Also decreases the mass gains of heart and lung in SHRs, suppresses cardiomyocyte cross-sectional area expansion, and inhibits the mRNA levels of atrial natriuretic peptide and brain natriuretic peptide[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male spontaneously hypertensive rats (SHRs, 50-week-old)[3]
Dosage: 0.15  μL/h (~50 μg/kg/day)
Administration: Administered by mini-osmotic pumps; for 6 weeks
Result: Attenuated hypertension, alleviated cardiac hypertrophy, and improved LV function.
Molecular Weight

855.00

Formula

C₄₀H₆₂N₁₂O₉

CAS No.

1176306-10-7

Sequence Shortening

ARVYIHP

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

H2O

Peptide Solubility and Storage Guidelines:

1.  Calculate the length of the peptide.

2.  Calculate the overall charge of the entire peptide according to the following table:

  Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.  Recommended solution:

Overall charge of peptide Details
Negative (<0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, add NH4OH (<50 μL).
3.  If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0) 1.  Try to dissolve the peptide in water first.
2.  If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.  If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.  Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.  For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

AlamandineAngiotensin ReceptorAngiotensin-converting Enzyme (ACE)Anti-hypertensiverenin-angiotensinMrgDvasoactivepeptidecardioprotectiveanti-fibroticInhibitorinhibitorinhibit

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Alamandine
目录号:
HY-P3108
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