2. Metabolic Enzyme/Protease Stem Cell/Wnt JAK/STAT Signaling Apoptosis
  3. Lipoxygenase β-catenin STAT Apoptosis
  4. ALOX5 stabilizer-1

ALOX5 stabilizer-1 是一种花生四烯酸 5-脂氧合酶（ALOX5）抑制剂，其 Kd 值为 7.26 μM。ALOX5 stabilizer-1 可抑制 β-catenin 的蛋白水平，并进而抑制 STAT3 信号通路。ALOX5 stabilizer-1 能诱导肺癌细胞凋亡 (apoptosis)，抑制细胞迁移和增殖。ALOX5 stabilizer-1 可用于非小细胞肺癌 (NSCLC) 的研究。

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ALOX5 stabilizer-1

ALOX5 stabilizer-1 Chemical Structure

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ALOX5 stabilizer-1 相关抗体

Top Publications Citing Use of Products

查看 Lipoxygenase 亚型特异性产品:

查看所有亚型
5-LOX 12-LOX 15-LOX

查看 STAT 亚型特异性产品:

查看所有亚型
STAT3 STAT5 STAT6 STAT1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ALOX5 stabilizer-1 is an arachidonate 5-lipoxygenase (ALOX5) stabilizer with a Kd of 7.26 μM. ALOX5 stabilizer-1 inhibits β-catenin protein levels and then suppresses STAT3 signal pathway. ALOX5 stabilizer-1 induces lung cancer cells apoptosis, inhibited cell migration and proliferation. ALOX5 stabilizer-1 can used for the study of non-small cell lung cancer (NSCLC)[1].

IC50 & Target[1]

STAT3

 

体外研究
(In Vitro)

ALOX5 stabilizer-1 (Compound 10d) (72 h) 抑制 NCI-H820 细胞增殖，IC50 为 0.11 μM，对 3T3 细胞的毒性较弱，IC50 为 0.48 μM[1]。
ALOX5 stabilizer-1 (0-0.2 μM, 10 d) 以剂量依赖性方式抑制 NCI-H820 细胞的集落形成[1]。
ALOX5 stabilizer-1 (0-0.2 μM, 48 h) 抑制 NCI-H820 细胞迁移并诱导细胞凋亡[1]。
ALOX5 stabilizer-1 (0-0.2 μM, 48 h) 直接靶向 ALOX5 蛋白并增强蛋白质稳定性，进而抑制 β-catenin 蛋白水平，最终抑制 NCI-H820 细胞中的 STAT3 信号通路[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ALOX5 stabilizer-1 相关抗体:

Cell Migration Assay [1]

Cell Line: NCI-H820 cells
Concentration: 0, 0.05, 0.1 and 0.2 μM
Incubation Time: 48 h
Result: Obviously inhibited migration in dose-dependent manner.

Apoptosis Analysis[1]

Cell Line: NCI-H820 cells
Concentration: 0, 0.05, 0.1 and 0.2 μM
Incubation Time: 48 h
Result: Increased the percentage of apoptosis.

Western Blot Analysis[1]

Cell Line: NCI-H820 cells
Concentration: 0, 0.02, 0.05, 0.1 and 0.2 μM
Incubation Time: 48 h
Result: Significantly decreased the expression of anti-apoptotic proteins Bcl-2 and Mcl-1 while increased the expression of apoptosis-related protein Bax in a dose-dependent manner.
Was directly bound to ALOX5 protein.
Inhibited both the nuclear translocation and protein levels of β-catenin.
Reduced the levels of STAT3 and p-STAT3.
分子量

552.62

Formula

C32H32N4O5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ALOX5 stabilizer-1 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ALOX5 stabilizer-1Lipoxygenaseβ-cateninSTATApoptosisLOXBeta cateninALOX5Anti-cancer activityChalconeParthenolideInhibitorinhibitorinhibit

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