Angiopeptin TFA  (Synonyms: 血管抑肽三氟乙酸盐)

Angiopeptin TFA, a cyclic octapeptide analogue of somatostatin, is a weak sst₂/sst₅ receptor partial agonist with IC₅₀ values of 0.26 nM and 6.92 nM, respectively. Angiopeptin TFA is a potent inhibitor of growth hormone release and insulin-like growth factor-1 (IGF-1) production. Angiopeptin TFA inhibits adenylate cyclase or stimulates extracellular acidification. Angiopeptin TFA has the potential for coronary atherosclerosis research^[1][2].

IC50: 0.26 nM (sst2) and 6.92 nM (sst5)^[1][2]

Angiopeptin (0.1 nM- 10 μM; for 1 h) TFA acts as a partial agonist (pEC₅₀=6.57) with a maximum response of 423% at 3 μM on the release of tritium on CHO hsst₂ cells^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Angiopeptin (20 and 50μg/kg; i.h.) TFA significantly inhibits neointimal formation^[1].
Angiopeptin (20 μg/kg; per day) TFA significantly inhibits coronary artery myointimal proliferation in cardiac allografts by appmximalely 50%^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

1326.39

C₅₈H₇₃F₆N₁₁O₁₄S₂

2478421-60-0

固体

White to off-white

{Nal}CYWKVCT-NH2

血管抑肽三氟乙酸盐

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

• [1]. Lundergan CF, et al. Peptide inhibition of myointimal proliferation by angiopeptin, a somatostatin analogue. J Am Coll Cardiol. 1991;17(6 Suppl B):132B-136B.  [Content Brief]

  [2]. Alderton F, et al. Somatostatin receptor-mediated arachidonic acid mobilization: evidence for partial agonism of synthetic peptides. Br J Pharmacol. 2001;132(3):760-766.  [Content Brief]