2. Anti-infection Immunology/Inflammation Cytoskeleton
  3. Bacterial Toll-like Receptor (TLR) Collagen
  4. Antibacterial agent 284

Antibacterial agent 284 (Compound 7) 是一种抗菌剂。Antibacterial agent 284 具有锌结合结构，对嗜肺军团菌 (Legionella pneumophila) 金属蛋白酶 ProA (IC50: 0.96 μM) 具有强效抑制活性。Antibacterial agent 284 可显著抑制 IV 型胶原蛋白和鞭毛蛋白 (ProA 底物) 的裂解，并降低人肺组织外植体中 TLR5-NF-κB 通路的免疫逃逸和中性粒细胞 (PMN) 介导的炎症。Antibacterial agent 284 具有军团病研究潜力。

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Antibacterial agent 284 Chemical Structure

Antibacterial agent 284 Chemical Structure

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Antibacterial agent 284 相关抗体

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生物活性

Antibacterial agent 284 (Compound 7) is an Antibacterial agent. Antibacterial agent 284 has a zinc-binding structure and potent inhibitory activity against Legionella pneumophila metalloprotease ProA (IC50: 0.96 μM) with zinc-binding structure. Antibacterial agent 284 significantly inactivates the cleavage of collagen IV and flagellin (ProA substrates) and reduces immune evasion from the TLR5-NF-κB pathway and PMN-mediated inflammation in human lung tissue explants. Antibacterial agent 284 is promising for Legionnaires' disease research[1].

分子量

439.27

Formula

C17H25Cl2N2O5P
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antibacterial agent 284 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antibacterial agent 284Antibacterial agent284Antibacterial agent-284BacterialToll-like Receptor (TLR)CollagenAntibacterialZinc-bindingMetalloprotease ProALegionella pneumophilaTLR5-NF-κB pathwayLegionnaires' diseaseInhibitorinhibitorinhibit

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