2. Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB Epigenetics Cell Cycle/DNA Damage PI3K/Akt/mTOR
  3. Apoptosis Reactive Oxygen Species (ROS) PARP Caspase Akt
  4. CHNQD-01426

CHNQD-01426 (Compound 4a) 是一种抗癌剂。CHNQD-01426 (Compound 4a) 对癌细胞具有细胞毒活性。CHNQD-01426 通过阻滞 S 期和 G2/M 期细胞周期显著抑制肝细胞癌细胞增殖，并通过诱导 ROS 产生和上调凋亡相关蛋白表达来诱导细胞凋亡 (apoptosis)。CHNQD-01426 有效抑制 HepG2异种移植小鼠模型中肿瘤生长。

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CHNQD-01426

CHNQD-01426 Chemical Structure

CAS No. : 2673232-30-7

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CHNQD-01426 相关抗体

Top Publications Citing Use of Products

查看 PARP 亚型特异性产品:

查看所有亚型
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

查看 Caspase 亚型特异性产品:

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

查看 Akt 亚型特异性产品:

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Akt Akt1 Akt2 Akt3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CHNQD-01426 (Compound 4a) is an anticancer agent. CHNQD-01426 has cytotoxic activities against cancer cells. CHNQD-01426 significantly inhibits hepatocellular carcinoma cells proliferation via arresting S and G2/M phase cell cycle and induces apoptosis by inducing ROS production and elevating apoptosis-related proteins expression. CHNQD-01426 potently inhibits tumor growth in HepG2 xenograft mice model[1][2].

IC50 & Target[1]

Caspase 3

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
A549 IC50
3.88 μM
Compound: 4a
Cytotoxicity against human A549 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
[PMID: 34237623]
Bel-7402 IC50
1.71 μM
Compound: 4a
Cytotoxicity against human Bel-7402 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
Cytotoxicity against human Bel-7402 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
[PMID: 34237623]
HCT-116 IC50
5.47 μM
Compound: 4a
Cytotoxicity against human HCT116 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
Cytotoxicity against human HCT116 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
[PMID: 34237623]
HepG2 IC50
1.22 μM
Compound: 4a
Cytotoxicity against human HepG2 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
[PMID: 34237623]
L02 IC50
6.01 μM
Compound: 4a
Cytotoxicity against human L-O2 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
Cytotoxicity against human L-O2 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
[PMID: 34237623]
NCI-H1299 IC50
13.94 μM
Compound: 4a
Cytotoxicity against human NCI-H1299 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
Cytotoxicity against human NCI-H1299 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
[PMID: 34237623]
U-251 IC50
5.48 μM
Compound: 4a
Cytotoxicity against human U251 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
Cytotoxicity against human U251 cells assessed as inhibition of proliferation incubated for 72 hrs by MTT assay
[PMID: 34237623]
分子量

340.33

Formula

C18H16N2O5
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CHNQD-01426 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CHNQD-014262673232-30-7CHNQD01426CHNQD 01426ApoptosisReactive Oxygen Species (ROS)PARPCaspaseAktpoly ADP ribose polymerase PKBProtein kinase BAnticancerCytotoxicHepG2 cellsBel-7402 cellsA549 cellsU251 cellsHepG2 xenograft mice modelInhibitorinhibitorinhibit

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目录号：
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