2. Apoptosis Cell Cycle/DNA Damage
  3. Apoptosis Topoisomerase
  4. Apoptosis inducer 54

Apoptosis inducer 54 是一种凋亡 (apoptosis) 诱导剂，可与拓扑异构酶 II-DNA (topoisomerase II-DNA)发生相互作用。Apoptosis inducer 54 可诱导癌细胞在 S 期发生细胞周期阻滞。Apoptosis inducer 54 可显著诱导 A549 细胞的早期和晚期凋亡。Apoptosis inducer 54 可用于肺癌和结肠癌的研究。

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Apoptosis inducer 54

Apoptosis inducer 54 Chemical Structure

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Apoptosis inducer 54 相关抗体

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Topoisomerase Topo I Topo II

  • 生物活性

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  • 参考文献

生物活性

Apoptosis inducer 54 is an apoptosis inducer that interacts with topoisomerase II-DNA. Apoptosis inducer 54 induces cell cycle arrest at the S phase in cancer cells. Apoptosis inducer 54 significantly induces early and late apoptosis in A549 cells. Topoisomerase I-IN-20 can be used for the research of lung cancer and colon cancer[1].

体外研究
(In Vitro)

Apoptosis inducer 54 (compound 9f) 表现出强效的抗增殖作用，对 A549 和 SW480 细胞的 IC50 值分别为 16.1 μM 和 19.7 μM。与正常细胞 MRC-5 相比，Apoptosis inducer 54 对 A549 和 SW480 癌细胞表现出显著的选择性[1]。
Apoptosis inducer 54 (16.1 μM；24-48 h；A549) 以时间依赖性方式诱导早期和晚期细胞凋亡[1]。
Apoptosis inducer 54 (16.1 μM；24-48 小时；A549) 在 S 期显示细胞周期阻滞[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis inducer 54 相关抗体:

Apoptosis Analysis[1]

Cell Line: A549
Concentration: 16.1 μM
Incubation Time: 24 h, 48 h
Result: Significantly induced early and late apoptosis in A549 cells after 48 h.

Cell Cycle Analysis[1]

Cell Line: A549
Concentration: 16.1 μM
Incubation Time: 24 h, 48 h
Result: Showed a significant increase in the number of cells in the S phase, along with a significant reduction in the number of cells in the G0/G1 phase, and a non-significant decrease in the G2/M phase.
分子量

558.59

Formula

C29H30N6O6
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Apoptosis inducer 54 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Apoptosis inducer 54Apoptosis inducer54Apoptosis inducer-54ApoptosisTopoisomerasetopoisomerase II-DNA,Apoptosis Inducer,cell cycle arrest,lung cancer and colon cancerInhibitorinhibitorinhibit

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