2. Apoptosis Immunology/Inflammation
  3. Apoptosis NO Synthase Interleukin Related COX
  4. ARN14494

ARN14494 是一种有效的选择性丝氨酸棕榈酰基转移酶 (SPT) 抑制剂，其 IC50 为 27.3 nM。ARN14494 在抗炎症和神经保护方面影响中枢神经系统。ARN14494 通过多种机制保护神经元免受 β-amyloid 1-42诱导的神经毒性，包括抗氧化、抗凋亡 (apoptosis) 和抗炎症。ARN14494 可用于阿尔茨海默病研究。

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ARN14494 Chemical Structure

ARN14494 Chemical Structure

CAS No. : 1037837-27-6

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ARN14494 相关抗体

Top Publications Citing Use of Products

查看 COX 亚型特异性产品:

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COX COX-1 COX-2 COX-3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ARN14494 is a potent and selective serine palmitoyltransferase (SPT) inhibitor, with an IC50 of 27.3 nM. ARN14494 affects the CNS in terms of anti-inflammation and neuroprotection. ARN14494 protects neurons from β-amyloid 1-42-induced neurotoxicity through a variety of mechanisms, including anti-oxidation, anti-apoptosis, and anti-inflammation. ARN14494 can be used for Alzheimer’s disease research[1].
IC50 & Target

IL-1β

 

iNOS

 

COX-2

 

体外研究
(In Vitro)

ARN14494 (1-10 μM) 对小鼠原代星形胶质细胞SPT活性的抑制作用呈浓度依赖性[1]。
ARN14494 (10 μM, 24 h) 降低Aβ1-42诱导的脑皮层星形胶质细胞神经酰胺和二氢神经酰胺水平[1]。
ARN14494 (10 μM, 0-24 h) 抑制原代星形胶质细胞培养中寡聚 Aβ 诱导的促炎分子(包括 NO、TNF-α、IL1β、TGF1β、促炎酶INOS和COX-2) 的产生[1]。
ARN14494 对皮质神经元 Aβ 神经毒性和 caspase-3 激活的影响[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

ARN14494 相关抗体:
分子量

424.54

Formula

C24H32N4O3
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

ARN14494 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ARN144941037837-27-6ARN 14494ARN-14494ApoptosisNO SynthaseInterleukin RelatedCOXNitric oxide synthasesNOSILCyclooxygenaseNeuro-2aCCF-STTG1 cellsmouse primary cortical astrocytesneuroprotectiveanti-oxidationanti-apoptosisanti-inflammationInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-115498
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