1. Autophagy
    Apoptosis
  2. Autophagy
    Apoptosis
  3. ARN5187 trihydrochloride

ARN5187 trihydrochloride 

目录号: HY-103691A
产品使用指南

ARN5187 trihydrochloride 是一种亲溶酶体 REV-ERBβ 配体,抑制 REV-ERB 介导的转录调控和细胞自噬。ARN5187 trihydrochloride 显示出溶酶体效力和细胞毒性。ARN5187 trihydrochloride 诱导细胞凋亡 (apoptosis)。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

ARN5187 trihydrochloride Chemical Structure

ARN5187 trihydrochloride Chemical Structure

CAS No. : 1700693-96-4

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 是否有货
100 mg   询价  
250 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of ARN5187 trihydrochloride:

注册 MCE会员完成审核
即刻享有 积分商城 300 专属积分

Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ARN5187 trihydrochloride is a lysosomotropic REV-ERBβ ligand with a dual inhibitory activity toward REV-ERB-mediated transcriptional regulation and autophagy. ARN5187 trihydrochloride shows lysosomotropic potency and cytotoxicity. ARN5187 trihydrochloride induces apoptosis[1][2].

IC50 & Target

REV-ERBβ[1]

体外研究
(In Vitro)

ARN5187 trihydrochloride (compound 1) (0-100 µM; 48 h) shows cytotoxicity with EC50 of 23.5 µM in BT-474 cells and IC50 of 30.14 µM, >100 µM for BT-474 and HMEC cells, respectively[1][2].
ARN5187 trihydrochloride (0-100 µM) activates the RevRE reporter in a concentration-dependent manner in HEK-293 cells[1].
ARN5187 trihydrochloride (25, 50 µM) is a lysosomotropic-independent REV-ERB antagonistic activity[1].
ARN5187 trihydrochloride (50 µM; 24 h) shows autophagy inhibition[1].
ARN5187 trihydrochloride (50 µM; 2, 8, 24 h) effects autophagy formation and maturation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay[1]

Cell Line: BT-474 cells
Concentration: 0-100 µM
Incubation Time: 48 h
Result: Showed cytotoxicity with EC50 of 23.5 µM.

Western Blot Analysis[1]

Cell Line: BT-474 cells
Concentration: 50 µM
Incubation Time: 24 h
Result: Significantly increased the expression of α-LC3-II, α-p62, α-Cleaved PARP.

RT-PCR[1]

Cell Line: BT-474 cells
Concentration: 25, 50 µM
Incubation Time:
Result: Significantly enhanced the expression of BMAL1, PER1 and PEPCK in a dose-dependent manner.
分子量

506.91

Formula

C24H35Cl3FN3O

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
ARN5187 trihydrochloride
目录号:
HY-103691A
需求量: