2. Cell Cycle/DNA Damage Epigenetics Apoptosis
  3. Aurora Kinase Apoptosis
  4. Aurkin A

Aurkin A 是一种变构抑制剂，可通过靶向 TPX2 结合位点 (Kd=3.77 μM)，抑制 Aurora A Kinase (也称为 Aurka) 与 TPX2 之间的相互作用。Aurkin A 可破坏 Alisertib (HY-10971) 诱导的多倍体，并增加肿瘤细胞凋亡 (apoptosis)。Aurkin A 可用于有丝分裂和肿瘤方面的研究。

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Aurkin A

Aurkin A Chemical Structure

CAS No. : 1534060-58-6

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Aurkin A 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Aurkin A is an allosteric inhibitor for the interaction between Aurora A Kinase (also known also Aurka) and TPX2, through targeting the TPX2 binding sites with Kd of 3.77 μM. Aurkin A can disrupt polyploidy induced by Alisertib (HY-10971) and increase apoptosis of tumor cells. Aurkin A can be used in research on mitosis and cancer[1][2].

体外研究
(In Vitro)

Aurkin A (10-1000 μM; 2 h) 在 HeLa 细胞中使 Aurka 在有丝分裂纺锤体微管上错位 (EC50: 85 μM)，并降低 T288 自磷酸化水平 (EC50: 135 μM)[1]。
Aurkin A (0-200 µM; 3-5 days) 在 U2932 细胞中可破坏 Alisertib (HY-10971) 诱导的多倍体并增加细胞凋亡[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Aurkin A 相关抗体:
体内研究
(In Vivo)

Aurkin A (30 mg/kg; 15 次, 共 4 周) 在皮下植入 VAL 细胞的小鼠中显著减少 Alisertib (HY-10971) 诱导的多倍体形成[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SCID mice treated VAL cells[2]
Dosage: 30 mg/kg
Administration: Once a day for five days a week. After two weeks, treatment was then withheld for a week, followed by another five-day-a-week treatment cycle
Result: Significantly reduced the proportion of polyploid cells induced by alisertib from 43.6% to 16.1%, compared to the alisertib-only group.
分子量

346.15

Formula

C16H9BrFNO2
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

Aurkin A 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aurkin A1534060-58-6Aurora KinaseApoptosisAllostericVAL cellsHeLa cellsU2932 cellsInhibitorinhibitorinhibit

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