2. Cell Cycle/DNA Damage PI3K/Akt/mTOR
  3. ATM/ATR
  4. AZ31

AZ31 是有效的、高选择性、具有口服活性的 ATM 的抑制剂，对 ATM 酶的 IC50 值 <1.2 nM，对细胞内 ATM 的 IC50 值为 46 nM。AZ31 表现出优异的 ATR 选择性 (>500 倍) 、PIKK 家族选择性和泛激酶选择性。AZ31 是一种强效的体外放射增敏剂，可用于癌症的研究。

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AZ31 Chemical Structure

AZ31 Chemical Structure

CAS No. : 2088113-98-6

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规格 价格 是否有货 数量
5 mg ￥1800
In-stock
10 mg ￥2900
In-stock
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100 mg   询价  

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Customer Review

AZ31 相关抗体

Top Publications Citing Use of Products

查看 ATM/ATR 亚型特异性产品:

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ATM ATR

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

AZ31 is a a potent, highly selective, and orally active ATM inhibitor with an IC50 of <1.2 nM for ATM enzyme, and an IC50 of 46 nM for ATM in cell. AZ31 shows excellent selectivity over ATR (>500-fold) and excellent PIKK-family selectivity and pan-kinase selectivity. AZ31 is a potent radiosensitizer in vitro, it can be used for the research of cancer[1].

IC50 & Target[1]

ATM

1.2 nM (IC50)

ATM

46 nM (IC50, in cell)

体外研究
(In Vitro)

AZ31 (0.3-3 μM; 1 h) affects phosphorylation of a panel of ATM targets[1].
AZ31 (10 μM; 1 h) affects stabilization of p53 in H2228 lung cancer cells after radiation[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

AZ31 相关抗体:

Western Blot Analysis[1]

Cell Line: Human glioma cell line
Concentration: 0.3, 1 and 3 μM
Incubation Time: 1 hour
Result: Blocked phosphorylation of p53-S15, KAP1-S824, and ATM auto-phosphorylation at S1981.

Western Blot Analysis[1]

Cell Line: H460 and mutant p53 H2228 cell lines
Concentration: 10 μM
Incubation Time: 1 hour
Result: Destabilized p53 of mutant p53 but not wild-type after radiation.
体内研究
(In Vivo)

AZ31 (50-100 mg/kg; p.o. twice a day) shows low brain coverage[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice[1]
Dosage: 50 and 100 mg/kg
Administration: Oral gavage; 50 and 100 mg/kg twice a day
Result: Exhibited exposure over IC50 at 0.046 μM in brain only for 2-3 hours.
分子量

420.50

Formula

C24H28N4O3
CAS 号
性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO 中的溶解度 : 100 mg/mL (237.81 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.3781 mL 11.8906 mL 23.7812 mL
5 mM 0.4756 mL 2.3781 mL 4.7562 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

AZ31 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3781 mL 11.8906 mL 23.7812 mL 59.4530 mL
5 mM 0.4756 mL 2.3781 mL 4.7562 mL 11.8906 mL
10 mM 0.2378 mL 1.1891 mL 2.3781 mL 5.9453 mL
15 mM 0.1585 mL 0.7927 mL 1.5854 mL 3.9635 mL
20 mM 0.1189 mL 0.5945 mL 1.1891 mL 2.9727 mL
25 mM 0.0951 mL 0.4756 mL 0.9512 mL 2.3781 mL
30 mM 0.0793 mL 0.3964 mL 0.7927 mL 1.9818 mL
40 mM 0.0595 mL 0.2973 mL 0.5945 mL 1.4863 mL
50 mM 0.0476 mL 0.2378 mL 0.4756 mL 1.1891 mL
60 mM 0.0396 mL 0.1982 mL 0.3964 mL 0.9909 mL
80 mM 0.0297 mL 0.1486 mL 0.2973 mL 0.7432 mL
100 mM 0.0238 mL 0.1189 mL 0.2378 mL 0.5945 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AZ312088113-98-6AZ 31AZ-31ATM/ATRAtaxia telangiectasia mutatedATM and RAD3 relatedradiosensitizerhuman gliomap53auto-phosphorylationKAP1-S824brain coveragemiceInhibitorinhibitorinhibit

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目录号：
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