Bevacizumab (PBS)  (Synonyms: 贝伐单抗 (PBS); Anti-Human VEGF, Humanized Antibody (PBS))

Bevacizumab, a humanized IgG1 monoclonal antibody, specifically binds to all VEGF-A isoforms with high affinity^[1][2].

Human IgG1 kappa

Human IgG1 kappa, Isotype Control

Human

VEGF-A

贝伐单抗是一种人源化单克隆抗体，能与所有VEGF-A亚型高亲和力特异性结合，并抑制其与VEGFR-1和VEGFR-2的相互作用^[1]。实验分析表明，经ELISA测定，贝伐单抗与VEGF结合的EC₅₀为0.18 μg/mL。结合动力学测定也显示出类似的结果，贝伐单抗抑制VEGF诱导的HUVEC增殖，IC₅₀值为0.047±0.0081 μg/mL^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

研究表明，与对照组相比，FD006 和贝伐单抗结膜下注射可显著抑制 NaOH 烧灼大鼠的 CoNV(p<0.01)^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

7422  [NCBI]

P15692

ELISA, FACS, Functional assay

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

146.56 kDa

216974-75-3

液体

Colorless to light yellow

贝伐单抗 (PBS)

Shipping with dry ice.

Please store the product under the recommended conditions in the Certificate of Analysis.

• 
  Human IgG1 kappa

• 
  Immobilized VEGF165 Protein, Human (HY-P7110A) can bind Bevacizumab. The EC₅₀ for this effect is 5.34 ng/mL.

• [1]. Tan H, et al. 99mTc-labeled bevacizumab for detecting atherosclerotic plaque linked to plaque neovascularization and monitoring antiangiogenic effects of treatment in ApoE-/-mice. Sci Rep. 2017 Jun 14;7(1):3504.  [Content Brief]

  [2]. Di Mauro C, et al. Hedgehog signalling pathway orchestrates angiogenesis in triple-negative breast cancers. Br J Cancer. 2017 May 23;116(11):1425-1435.  [Content Brief]