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  4. C24-Ceramide

C24-Ceramide  (Synonyms: N-二十四酰基鞘氨醇)

目录号: HY-134508 纯度: 99.92%
COA 产品使用指南 技术支持

C24-Ceramide 是一种口服有效的 PIP4K2C (mTOR 复合物调节因子) 的竞争性结合激动剂，从而激活 mTOR 信号通路。同时，C24-Ceramide 通过诱导磷脂双分子层形成部分互锁凝胶相改变膜形态。C24-Ceramide 能够促进角质形成细胞增殖迁移以加速皮肤伤口愈合、驱动胆囊癌细胞增殖转移。血清中 C24-Ceramide 水平可作为胆囊癌诊断标志物。

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C24-Ceramide

C24-Ceramide Chemical Structure

CAS No. : 34435-05-7

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Other Forms of C24-Ceramide:

C24-Ceramide 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

C24-Ceramide is an orally active competitive binding agonist of PIP4K2C (mTOR complex regulator), thereby activating the mTOR signaling pathway. At the same time, C24-Ceramide changes the membrane morphology by inducing the formation of a partially interlocked gel phase in the phospholipid bilayer. C24-Ceramide can promote the proliferation and migration of keratinocytes to accelerate skin wound healing and drive the proliferation and metastasis of gallbladder cancer cells. The level of C24-Ceramide in serum can be used as a diagnostic marker for gallbladder cancer[1][2][3].

体外研究
(In Vitro)

C24-Ceramide (100 μg/mL；48 h) 在人角质形成细胞 (HaCaT) 中显著促进细胞增殖与迁移[2]。
C24-Ceramide (500 μg/mL；24 h) 可激活 AKT 和 ERK1/2 信号通路[2]。
C24-Ceramide (100 nM；12 h) 在胆囊癌细胞 (GBC-SD、NOZ) 中通过结合 PIP4K2C 激活 mTOR 信号，促进细胞增殖与迁移，而 C6-Ceramide 可竞争性抑制该作用[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

C24-Ceramide 相关抗体:

Cell Viability Assay[2][3]

Cell Line: HaCaT, GBC-SD, NOZ
Concentration: 100 μg/mL for HaCaT cells, 100 nM for GBC-SD, NOZ cells
Incubation Time: 24-48 h
Result: Promoted cell migration in HaCaT and GBC cells. Enhanced membrane flexibility that facilitates cell movement.
体内研究
(In Vivo)

C24-Ceramide (4.4 μg/次；局部涂抹；每日 1 次；10 天) 在 HR-1 无毛小鼠皮肤伤口模型中加速伤口闭合，促进表皮和真皮再生及胶原蛋白沉积[2]。
C24-Ceramide (10 mg/kg；饮食添加；每日 1 次；3 周) 在裸鼠皮下移植瘤模型中促进胆囊癌 (GBC-SD 细胞) 生长，表现为肿瘤体积增大、重量增加，以及 Ki-67 阳性细胞比例升高[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male HR-1 hairless mice (6-week-old, 18-20 g), full-thickness skin wound model[2]
Dosage: 4.4 μg C24-Ceramide per dose (formulated as C24-LNP in deionized water)
Administration: Topical application (10 μL of 1 mg/mL C24-LNP) daily for 10 days
Result: Significantly accelerated wound closure.
Enhanced re-epithelialization, increased fibroblast proliferation, and improved collagen deposition in the dermis, as confirmed by Masson’s trichrome staining.
Activated AKT and ERK1/2 signaling pathways in wound tissues, promoting cell proliferation and migration.
Animal Model: Nude mice subcutaneous xenograft model with GBC-SD cells[3]
Dosage: 10 mg/kg
Administration: Daily oral administration via dietary addition for 3 consecutive weeks
Result: Significantly increased tumor size and Ki-67 reactivity in xenograft sections, indicating enhanced cell proliferation.
Promoted hepatic metastasis, with higher incidence and size of metastatic lesions compared to control.
Activated mTOR signaling through binding to PIP4K2C, which was antagonized by C6-Ceramide co-treatment.
分子量

650.11

Formula

C42H83NO3
CAS 号
性状

固体

颜色

White to off-white

中文名称

N-二十四酰基鞘氨醇
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
细胞实验： 

Ethanol 中的溶解度 : 25 mg/mL (38.46 mM; 超声助溶)

THF 中的溶解度 : 25 mg/mL (38.46 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.5382 mL 7.6910 mL 15.3820 mL
5 mM 0.3076 mL 1.5382 mL 3.0764 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.92%

COA (275 KB) HNMR (284 KB) RP-HPLC (222 KB)

产品使用指南 (1538 KB)
参考文献

C24-Ceramide 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
Ethanol / THF 1 mM 1.5382 mL 7.6910 mL 15.3820 mL 38.4550 mL
5 mM 0.3076 mL 1.5382 mL 3.0764 mL 7.6910 mL
10 mM 0.1538 mL 0.7691 mL 1.5382 mL 3.8455 mL
15 mM 0.1025 mL 0.5127 mL 1.0255 mL 2.5637 mL
20 mM 0.0769 mL 0.3846 mL 0.7691 mL 1.9228 mL
25 mM 0.0615 mL 0.3076 mL 0.6153 mL 1.5382 mL
30 mM 0.0513 mL 0.2564 mL 0.5127 mL 1.2818 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

C24-Ceramide34435-05-7N-二十四酰基鞘氨醇mTORMammalian target of Rapamycinlipid membranesmembrane reorganizationInhibitorinhibitorinhibit

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