2. Metabolic Enzyme/Protease Cell Cycle/DNA Damage Apoptosis
  3. Carbonic Anhydrase CDK Apoptosis
  4. CAIX/CDK-2-IN-1

CAIX/CDK-2-IN-1 是一种双重作用抑制剂，可抑制碳酸酐酶 IX (CA IX) 和细胞周期蛋白依赖性激酶 2 (CDK-2)，其 IC50 值分别为 0.29 μM 和 0.32 μM。CAIX/CDK-2-IN-1 的玉米醇溶蛋白纳米颗粒可诱导癌细胞凋亡 (apoptosis)。CAIX/CDK-2-IN-1 可用于癌症研究，如肺癌。

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CAIX/CDK-2-IN-1

CAIX/CDK-2-IN-1 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

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Customer Review

CAIX/CDK-2-IN-1 相关抗体

Top Publications Citing Use of Products

查看 Carbonic Anhydrase 亚型特异性产品:

查看所有亚型
CA CA I CA Ⅱ CA IX CA XII

查看 CDK 亚型特异性产品:

查看所有亚型
CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85 CDK10 CDK15 CDK17 CDK18 CDK20 PITSLRE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CAIX/CDK-2-IN-1 is a dual-acting inhibitor of carbonic anhydrase IX (CA IX) and cyclin-dependent kinase-2 (CDK-2) with IC50 values of 0.29 μM and 0.32 μM. The zein nanoparticls of CAIX/CDK-2-IN-1 can induce cancer cells apoptosis. CAIX/CDK-2-IN-1 can be used for the research of cancer, such as ling cancer[1].

IC50 & Target[1]

CA IX

0.29 μM (IC50)

CDK2

0.32 μM (IC50)

体外研究
(In Vitro)

CAIX/CDK-2-IN-1 (Compound 5c) (Zein NPs) (10 μM) 在 A549 细胞中显示出 94.8% 的细胞生长抑制率 (GI%)，然而其游离体的 GI% 仅为 3%[1]。
CAIX/CDK-2-IN-1 (Zein NPs) (48 h) 可诱导 A549 细胞凋亡，上调 P53、Bax、PUMA 和 Caspase-3/8/9 基因的表达，并下调 Bcl-2 的表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CAIX/CDK-2-IN-1 相关抗体:
体内研究
(In Vivo)

CAIX/CDK-2-IN-1 (Compound 5c) (Zein NPs) (6 mg/kg，鼻内给药，从第 17 周到第 20 周每天给药) 在经 Urethane (HY-B1207) 诱导的肺癌 BALB/c 小鼠中显示出抗肿瘤活性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c mice with Urethane (HY-B1207)-induced lung cancer[1]
Dosage: 6 mg/kg (Zein NPs)
Administration: Intranasally administration, daily from week 17 to 20
Result: Reduced the lung index (relative lung weight from 2.91 to 1.35) .
Decreased lung weight (from 567.4±26.7 mg to 298.6±16.4 mg).
Inhibited the protein expression of hCA IX, hCA XII and CDK-2 by 45%, 58% and 46% respectively.
Improved the 20-week survival rate of mice to 40%.
分子量

584.09

Formula

C25H18ClN5O4S3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

CAIX/CDK-2-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CAIX/CDK-2-IN-1Carbonic AnhydraseCDKApoptosisCarbonate dehydrataseCyclin dependent kinasecarbonic anhydrase IXhCA IXcyclin-dependent kinase-2CDK-2A549P53BaxPUMAcancerInhibitorinhibitorinhibit

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